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Literature DB >> 24164576

Gene regulation by non-coding RNAs.

Abstract

The past two decades have seen an explosion in research on non-coding RNAs and their physiological and pathological functions. Several classes of small (20-30 nucleotides) and long (>200 nucleotides) non-coding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long non-coding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
RNA, Untranslated

Year: 2013 PMID： 24164576 PMCID： PMC4721600 DOI： 10.3109/10409238.2013.844092

Source DB: PubMed Journal: Crit Rev Biochem Mol Biol ISSN： 1040-9238 Impact factor: 8.250

232 in total

Review 1. The widespread regulation of microRNA biogenesis, function and decay.

Authors: Jacek Krol; Inga Loedige; Witold Filipowicz
Journal: Nat Rev Genet Date: 2010-07-27 Impact factor: 53.242

Review 2. X-inactivation, imprinting, and long noncoding RNAs in health and disease.

Authors: Jeannie T Lee; Marisa S Bartolomei
Journal: Cell Date: 2013-03-14 Impact factor: 41.582

Review 3. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants.

Authors: Jr-Shiuan Yang; Eric C Lai
Journal: Mol Cell Date: 2011-09-16 Impact factor: 17.970

4. siRNA-mediated gene silencing in vitro and in vivo.

Authors: Haibin Xia; Qinwen Mao; Henry L Paulson; Beverly L Davidson
Journal: Nat Biotechnol Date: 2002-09-16 Impact factor: 54.908

5. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.

Authors: Masanobu Shoji; Takashi Tanaka; Mihoko Hosokawa; Michael Reuter; Alexander Stark; Yuzuru Kato; Gen Kondoh; Katsuya Okawa; Takeshi Chujo; Tsutomu Suzuki; Kenichiro Hata; Sandra L Martin; Toshiaki Noce; Satomi Kuramochi-Miyagawa; Toru Nakano; Hiroyuki Sasaki; Ramesh S Pillai; Norio Nakatsuji; Shinichiro Chuma
Journal: Dev Cell Date: 2009-12 Impact factor: 12.270

6. Interferon modulation of cellular microRNAs as an antiviral mechanism.

Authors: Irene M Pedersen; Guofeng Cheng; Stefan Wieland; Stefano Volinia; Carlo M Croce; Francis V Chisari; Michael David
Journal: Nature Date: 2007-10-18 Impact factor: 49.962

7. An endogenous small interfering RNA pathway in Drosophila.

Authors: Benjamin Czech; Colin D Malone; Rui Zhou; Alexander Stark; Catherine Schlingeheyde; Monica Dus; Norbert Perrimon; Manolis Kellis; James A Wohlschlegel; Ravi Sachidanandam; Gregory J Hannon; Julius Brennecke
Journal: Nature Date: 2008-05-07 Impact factor: 49.962

8. Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

Authors: Ryan L Boudreau; Jodi L McBride; Inês Martins; Shihao Shen; Yi Xing; Barrie J Carter; Beverly L Davidson
Journal: Mol Ther Date: 2009-02-24 Impact factor: 11.454

9. The reality of pervasive transcription.

Authors: Michael B Clark; Paulo P Amaral; Felix J Schlesinger; Marcel E Dinger; Ryan J Taft; John L Rinn; Chris P Ponting; Peter F Stadler; Kevin V Morris; Antonin Morillon; Joel S Rozowsky; Mark B Gerstein; Claes Wahlestedt; Yoshihide Hayashizaki; Piero Carninci; Thomas R Gingeras; John S Mattick
Journal: PLoS Biol Date: 2011-07-12 Impact factor: 8.029

Review 10. Developmental functions of the Distal-less/Dlx homeobox genes.

Authors: Grace Panganiban; John L R Rubenstein
Journal: Development Date: 2002-10 Impact factor: 6.868

64 in total

1. GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells.

Authors: Zhen Yang; Qi Sun; Junfei Guo; Shixing Wang; Ge Song; Weiying Liu; Min Liu; Hua Tang
Journal: Autophagy Date: 2018-11-05 Impact factor: 16.016

10. Comprehensive analysis of differentially expressed non-coding RNAs and mRNAs in gastric cancer cells under hypoxic conditions.

Authors: Jia Li; Xinjing Wang; Wenli Lu; Yuan Xiao; Yi Yu; Xinqiong Wang; Chundi Xu; Baiyong Shen
Journal: Am J Transl Res Date: 2018-03-15 Impact factor: 4.060

Gene regulation by non-coding RNAs.

Review 1. The widespread regulation of microRNA biogenesis, function and decay.

Review 2. X-inactivation, imprinting, and long noncoding RNAs in health and disease.

Review 3. Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants.

4. siRNA-mediated gene silencing in vitro and in vivo.

5. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.

6. Interferon modulation of cellular microRNAs as an antiviral mechanism.

7. An endogenous small interfering RNA pathway in Drosophila.

8. Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

9. The reality of pervasive transcription.

Review 10. Developmental functions of the Distal-less/Dlx homeobox genes.

1. GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells.

2. Inverse folding with RNA-As-Graphs produces a large pool of candidate sequences with target topologies.

3. An extended dual graph library and partitioning algorithm applicable to pseudoknotted RNA structures.

Review 4. Extracellular RNA mediates and marks cancer progression.

5. Primer in Genetics and Genomics, Article 6: Basics of Epigenetic Control.

6. MicroRNA biomarkers for early detection of embryonic malformations in pregnancy.

7. APERO: a genome-wide approach for identifying bacterial small RNAs from RNA-Seq data.

Review 8. Biology and clinical relevance of noncoding sno/scaRNAs.

9. Grad-seq guides the discovery of ProQ as a major small RNA-binding protein.

10. Comprehensive analysis of differentially expressed non-coding RNAs and mRNAs in gastric cancer cells under hypoxic conditions.