| Literature DB >> 22936568 |
Matthias Meyer1, Martin Kircher, Marie-Theres Gansauge, Heng Li, Fernando Racimo, Swapan Mallick, Joshua G Schraiber, Flora Jay, Kay Prüfer, Cesare de Filippo, Peter H Sudmant, Can Alkan, Qiaomei Fu, Ron Do, Nadin Rohland, Arti Tandon, Michael Siebauer, Richard E Green, Katarzyna Bryc, Adrian W Briggs, Udo Stenzel, Jesse Dabney, Jay Shendure, Jacob Kitzman, Michael F Hammer, Michael V Shunkov, Anatoli P Derevianko, Nick Patterson, Aida M Andrés, Evan E Eichler, Montgomery Slatkin, David Reich, Janet Kelso, Svante Pääbo.
Abstract
We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.Entities:
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Year: 2012 PMID： 22936568 PMCID： PMC3617501 DOI： 10.1126/science.1224344
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728