Literature DB >> 11060447

The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.

Y Liu1, E McKenna, D J Figueroa, R Blevins, C P Austin, P B Bennett, R Swanson.   

Abstract

A novel human Kir5.1 (inward rectifier K+ channel subunit, gene name KCNJ16) was identified through database searches. This human KCNJ16 was mapped to chromosome 17q25. The full-length cDNA was identified and its genomic structure was determined. Tissue distribution studies showed that human KCNJ16 is significantly expressed in human kidney, pancreas and thyroid gland. In situ hybridization revealed expression in convoluted tubule cells of kidney and in the acinar and ductal cells of pancreas. These suggest that human Kir5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease. Copyright 2000 S. Karger AG, Basel.

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Year:  2000        PMID： 11060447     DOI： 10.1159/000015662

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  9 in total

Review 1.  Potassium channels in epithelial transport.

Authors:  Richard Warth
Journal:  Pflugers Arch       Date:  2003-04-18       Impact factor: 3.657

2.  A high-coverage genome sequence from an archaic Denisovan individual.

Authors:  Matthias Meyer; Martin Kircher; Marie-Theres Gansauge; Heng Li; Fernando Racimo; Swapan Mallick; Joshua G Schraiber; Flora Jay; Kay Prüfer; Cesare de Filippo; Peter H Sudmant; Can Alkan; Qiaomei Fu; Ron Do; Nadin Rohland; Arti Tandon; Michael Siebauer; Richard E Green; Katarzyna Bryc; Adrian W Briggs; Udo Stenzel; Jesse Dabney; Jay Shendure; Jacob Kitzman; Michael F Hammer; Michael V Shunkov; Anatoli P Derevianko; Nick Patterson; Aida M Andrés; Evan E Eichler; Montgomery Slatkin; David Reich; Janet Kelso; Svante Pääbo
Journal:  Science       Date:  2012-08-30       Impact factor: 47.728

Review 3.  The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel.

Authors:  Sascha Bandulik; Katharina Schmidt; Detlef Bockenhauer; Anselm A Zdebik; Evelyn Humberg; Robert Kleta; Richard Warth; Markus Reichold
Journal:  Pflugers Arch       Date:  2011-01-11       Impact factor: 3.657

Review 4.  Kir5.1 channels: potential role in epilepsy and seizure disorders.

Authors:  Alexander Staruschenko; Matthew R Hodges; Oleg Palygin
Journal:  Am J Physiol Cell Physiol       Date:  2022-07-18       Impact factor: 5.282

5.  Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.

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Journal:  Nat Genet       Date:  2012-08-05       Impact factor: 38.330

Review 6.  Potassium channels in pancreatic duct epithelial cells: their role, function and pathophysiological relevance.

Authors:  Viktória Venglovecz; Zoltán Rakonczay; Michael A Gray; Péter Hegyi
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Authors:  Arne Pfeufer; Serena Sanna; Dan E Arking; Martina Müller; Vesela Gateva; Christian Fuchsberger; Georg B Ehret; Marco Orrú; Cristian Pattaro; Anna Köttgen; Siegfried Perz; Gianluca Usala; Maja Barbalic; Man Li; Benno Pütz; Angelo Scuteri; Ronald J Prineas; Moritz F Sinner; Christian Gieger; Samer S Najjar; W H Linda Kao; Thomas W Mühleisen; Mariano Dei; Christine Happle; Stefan Möhlenkamp; Laura Crisponi; Raimund Erbel; Karl-Heinz Jöckel; Silvia Naitza; Gerhard Steinbeck; Fabio Marroni; Andrew A Hicks; Edward Lakatta; Bertram Müller-Myhsok; Peter P Pramstaller; H-Erich Wichmann; David Schlessinger; Eric Boerwinkle; Thomas Meitinger; Manuela Uda; Josef Coresh; Stefan Kääb; Gonçalo R Abecasis; Aravinda Chakravarti
Journal:  Nat Genet       Date:  2009-03-22       Impact factor: 38.330

Review 8.  Ion Channel Signature in Healthy Pancreas and Pancreatic Ductal Adenocarcinoma.

Authors:  Julie Schnipper; Isabelle Dhennin-Duthille; Ahmed Ahidouch; Halima Ouadid-Ahidouch
Journal:  Front Pharmacol       Date:  2020-10-16       Impact factor: 5.810

9.  Contrasting signatures of genomic divergence during sympatric speciation.

Authors:  Andreas F Kautt; Claudius F Kratochwil; Alexander Nater; Gonzalo Machado-Schiaffino; Melisa Olave; Frederico Henning; Julián Torres-Dowdall; Andreas Härer; C Darrin Hulsey; Paolo Franchini; Martin Pippel; Eugene W Myers; Axel Meyer
Journal:  Nature       Date:  2020-10-28       Impact factor: 49.962
  9 in total

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