PURPOSE: To investigate the role of silicone oil as an adjunct to iodine 125 ((125)I) brachytherapy in attenuating radiation dose and reducing radiation retinopathy. METHODS: A 16-mm COMS plaque loaded with (125)I seeds was simulated in vitro on an eye model containing silicone oil as a vitreous substitute using BrachyDose. The radiation dose ratio of silicone oil vs water to ocular structures was calculated at angles subtended from the centre of the eye. Silicone oil was then used in three choroidal melanoma patients who underwent 23-gauge vitrectomy, silicone oil placement, and (125)I brachytherapy. RESULTS: Silicone oil reduced the ocular radiation dose in vitro to 65%. Radiation dose ratios on the retina increased from 0.45 to 0.99 when moving from points diametrically opposed to the plaque's central axis. In 10-24 months' follow-up, no patients have developed radiation retinopathy. Each patient required silicone oil removal and experienced cataract progression, and one also developed a retinal detachment. CONCLUSIONS: This study confirms that silicone oil attenuates radiation dose in vitro, and may protect against radiation retinopathy clinically in patients, however it requires extensive surgical interventions. Further studies in only very selected populations using silicone oil as an adjunct to (125)I brachytherapy will best elucidate its role in shielding radiation retinopathy.
PURPOSE: To investigate the role of silicone oil as an adjunct to iodine 125 ((125)I) brachytherapy in attenuating radiation dose and reducing radiation retinopathy. METHODS: A 16-mm COMS plaque loaded with (125)I seeds was simulated in vitro on an eye model containing silicone oil as a vitreous substitute using BrachyDose. The radiation dose ratio of silicone oil vs water to ocular structures was calculated at angles subtended from the centre of the eye. Silicone oil was then used in three choroidal melanomapatients who underwent 23-gauge vitrectomy, silicone oil placement, and (125)I brachytherapy. RESULTS:Silicone oil reduced the ocular radiation dose in vitro to 65%. Radiation dose ratios on the retina increased from 0.45 to 0.99 when moving from points diametrically opposed to the plaque's central axis. In 10-24 months' follow-up, no patients have developed radiation retinopathy. Each patient required silicone oil removal and experienced cataract progression, and one also developed a retinal detachment. CONCLUSIONS: This study confirms that silicone oil attenuates radiation dose in vitro, and may protect against radiation retinopathy clinically in patients, however it requires extensive surgical interventions. Further studies in only very selected populations using silicone oil as an adjunct to (125)I brachytherapy will best elucidate its role in shielding radiation retinopathy.
Authors: J M Quivey; D H Char; T L Phillips; K A Weaver; J R Castro; S M Kroll Journal: Int J Radiat Oncol Biol Phys Date: 1993-07-15 Impact factor: 7.038
Authors: Svetomir N Markovic; Lori A Erickson; Ravi D Rao; Roger H Weenig; Barbara A Pockaj; Aditya Bardia; Celine M Vachon; Steven E Schild; Robert R McWilliams; Jennifer L Hand; Susan D Laman; Lisa A Kottschade; William J Maples; Mark R Pittelkow; Jose S Pulido; J Douglas Cameron; Edward T Creagan Journal: Mayo Clin Proc Date: 2007-04 Impact factor: 7.616
Authors: Kenneth J Taubenslag; Stephen J Kim; Albert Attia; Ty W Abel; Hilary Highfield Nickols; Kristin K Ancell; Anthony B Daniels Journal: Digit J Ophthalmol Date: 2015-10-05