Literature DB >> 22931853

A bigger picture: classical cadherins and the dynamic actin cytoskeleton.

Aparna Ratheesh1, Alpha S Yap.   

Abstract

Classical cadherin adhesion receptors influence tissue integrity in health and disease. Their biological function is intimately linked to the actin cytoskeleton. To date, research has largely focused on identifying the molecular mechanisms that physically couple cadherin to cortical actin filaments. However, the junctional cytoskeleton is dynamic. Recent developments in understanding how filament dynamics and organization in the junctional cytoskeleton are controlled provide new insights into how the actin cytoskeleton regulates cadherin junctions in health and disease.

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Year:  2012        PMID： 22931853     DOI： 10.1038/nrm3431

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  83 in total

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  65 in total

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