BACKGROUND: The Neuropsychiatric Inventory (NPI) and the Frontal Behavioral Inventory (FBI) are widely used in patients with the behavioral variant of frontotemporal dementia (bvFTD). Yet, few data are available on the long-term relevance of these scales. MATERIAL AND METHODS: Based on a bvFTD population that participated in the Memantine Clinical Trial (NCT00200538), we studied the evolution and correlation between scores obtained on behavioral scales (NPI and FBI), cognitive scales [Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS)] and a burden scale [Zarit Burden Inventory (ZBI)]. The assessments were performed at 1 year in 41 patients and at 2 years in 23 patients who agreed to participate in this open-label study. RESULTS: The 2-year scores obtained on the FBI were significantly higher than the scores at inclusion while those obtained on the NPI did not change. There were significant correlations between the FBI, and the MDRS and MMSE, especially regarding the negative items. The ZBI correlated with behavioral scales at all stages for positive items. CONCLUSIONS: This study based on a large population shows that the FBI is a better tool than the NPI for the long-term assessment of bvFTD patients. Moreover, the FBI allows a distinction to be made between behavioral disturbances that involve cognitive functions from those which have an important impact on caregiver burden.
BACKGROUND: The Neuropsychiatric Inventory (NPI) and the Frontal Behavioral Inventory (FBI) are widely used in patients with the behavioral variant of frontotemporal dementia (bvFTD). Yet, few data are available on the long-term relevance of these scales. MATERIAL AND METHODS: Based on a bvFTD population that participated in the Memantine Clinical Trial (NCT00200538), we studied the evolution and correlation between scores obtained on behavioral scales (NPI and FBI), cognitive scales [Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS)] and a burden scale [Zarit Burden Inventory (ZBI)]. The assessments were performed at 1 year in 41 patients and at 2 years in 23 patients who agreed to participate in this open-label study. RESULTS: The 2-year scores obtained on the FBI were significantly higher than the scores at inclusion while those obtained on the NPI did not change. There were significant correlations between the FBI, and the MDRS and MMSE, especially regarding the negative items. The ZBI correlated with behavioral scales at all stages for positive items. CONCLUSIONS: This study based on a large population shows that the FBI is a better tool than the NPI for the long-term assessment of bvFTD patients. Moreover, the FBI allows a distinction to be made between behavioral disturbances that involve cognitive functions from those which have an important impact on caregiver burden.
Authors: Shunichiro Shinagawa; Joseree Ann Catindig; Nikolas R Block; Bruce L Miller; Katherine P Rankin Journal: Dement Geriatr Cogn Disord Date: 2016-01-08 Impact factor: 2.959
Authors: Alberto Benussi; Enrico Premi; Stefano Gazzina; Chiara Brattini; Elisa Bonomi; Antonella Alberici; Lize Jiskoot; John C van Swieten; Raquel Sanchez-Valle; Fermin Moreno; Robert Laforce; Caroline Graff; Matthis Synofzik; Daniela Galimberti; Mario Masellis; Carmela Tartaglia; James B Rowe; Elizabeth Finger; Rik Vandenberghe; Alexandre de Mendonça; Fabrizio Tagliavini; Isabel Santana; Simon Ducharme; Chris R Butler; Alexander Gerhard; Johannes Levin; Adrian Danek; Markus Otto; Giovanni Frisoni; Roberta Ghidoni; Sandro Sorbi; Isabelle Le Ber; Florence Pasquier; Georgia Peakman; Emily Todd; Martina Bocchetta; Jonathan D Rohrer; Barbara Borroni Journal: JAMA Netw Open Date: 2021-01-04
Authors: Michael Guger; Stefan Raschbacher; Lukas Kellermair; Milan R Vosko; Christian Eggers; Thomas Forstner; Karin Leitner; Alexandra Fuchs; Franz Fellner; Gerhard Ransmayr Journal: J Neural Transm (Vienna) Date: 2021-07-19 Impact factor: 3.575