Literature DB >> 22920393

Targeted pharmacogenetic analysis of antipsychotic response in the CATIE study.

Qian Liu1, Maidar Jamba, Calvin Patrick, Saranya Padmanabhan, Mark D Brennan.   

Abstract

AIM: This study evaluated the impact of 6789 SNPs on treatment response to antipsychotics in Caucasian patients from the CATIE study. MATERIALS &
METHODS: An Illumina (CA, USA) BeadChip was designed that targeted genes potentially impacting disease risk, disease presentation or antipsychotic response. SNPs tagged regions of linkage disequilibrium or functional variants not detectable using previous genotypes for CATIE. Change in Positive and Negative Syndrome scale total score was modeled using a mixed model repeated measures method that assumed a 30-day lag period. Genetic association analysis was performed using linear regression.
RESULTS: Association analysis identified 20 SNPs with p-values of ≤5 × 10(-4). Many of these are in genes previously implicated in schizophrenia and other neuropsychiatric diseases.
CONCLUSION: The targeted approach identified SNPs possibly influencing response to antipsychotic drugs in Caucasian patients suffering from schizophrenia. The findings support a biological link between disease risk and presentation and antipsychotic response.

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Year:  2012        PMID： 22920393      PMCID： PMC3518380          DOI： 10.2217/pgs.12.105

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  59 in total

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  6 in total

1.  Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE study.

Authors:  Timothy L Ramsey; Qian Liu; Bill W Massey; Mark D Brennan
Journal:  Schizophr Res       Date:  2013-07-23       Impact factor: 4.939

2.  Replication of SULT4A1-1 as a pharmacogenetic marker of olanzapine response and evidence of lower weight gain in the high response group.

Authors:  Timothy L Ramsey; Qian Liu; Mark D Brennan
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3.  Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen.

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4.  Glucagon-like peptide 1 receptor (GLP1R) haplotypes correlate with altered response to multiple antipsychotics in the CATIE trial.

Authors:  Timothy L Ramsey; Mark D Brennan
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5.  Risk gene-set and pathways in 22q11.2 deletion-related schizophrenia: a genealogical molecular approach.

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