BACKGROUND: Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied. OBJECTIVES: The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch. METHODS: The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP). IMPLICATIONS: Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.
BACKGROUND: Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied. OBJECTIVES: The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. The secondary objectives are to investigate the prevalence and predictors of prosthesis-related complications including prosthesis-patient mismatch. METHODS: The PROSTAVA study, a multicentre cross-sectional observational study, will include approximately 550 ACHD patients with prosthetic valves. Primary outcome measures are maximum oxygen uptake during cardiopulmonary exercise testing and QoL. Secondary outcomes are the prevalence and incidence of valve-related complications including prosthesis-patient mismatch. Other evaluations are medical history, physical examination, echocardiography, MRI, rhythm monitoring and laboratory evaluation (including NT-proBNP). IMPLICATIONS: Identification of the relation between prosthetic valve characteristics in ACHD patients on one hand and functional outcome, QoL, the prevalence and predictors of prosthesis-related complications on the other hand may influence the choice of valve prosthesis, the indication for more extensive surgery and the indication for re-operation.
Authors: Thomas Oosterhof; Folkert J Meijboom; Hubert W Vliegen; Mark G Hazekamp; Aeiko H Zwinderman; Berto J Bouma; Arie P J van Dijk; Barbara J M Mulder Journal: Eur Heart J Date: 2006-05-17 Impact factor: 29.983
Authors: John M Stulak; Joseph A Dearani; Harold M Burkhart; Heidi M Connolly; Carole A Warnes; Rakesh M Suri; Hartzell V Schaff Journal: Ann Thorac Surg Date: 2010-12 Impact factor: 4.330
Authors: Giordano Tasca; Zen Mhagna; Silvano Perotti; Pietro Berra Centurini; Tony Sabatini; Andrea Amaducci; Federico Brunelli; Marco Cirillo; Margherita Dalla Tomba; Eugenio Quaini; Eugenio Quiani; Giovanni Troise; Philippe Pibarot Journal: Circulation Date: 2006-01-09 Impact factor: 29.690
Authors: R C Schoonbeek; P G Pieper; Y J van Slooten; H G Freling; G T Sieswerda; A P J van Dijk; M R M Jongbloed; M C Post; B J Bouma; R M F Berger; T Ebels; J P van Melle Journal: Neth Heart J Date: 2016-11 Impact factor: 2.380