Literature DB >> 22914648

Increased expression and aberrant localization of mucin 13 in metastatic colon cancer.

Brij K Gupta1, Diane M Maher, Mara C Ebeling, Vasudha Sundram, Michael D Koch, Douglas W Lynch, Teresa Bohlmeyer, Akira Watanabe, Hiroyuki Aburatani, Susan E Puumala, Meena Jaggi, Subhash C Chauhan.   

Abstract

MUC13 is a newly identified transmembrane mucin. Although MUC13 is known to be overexpressed in ovarian and gastric cancers, limited information is available regarding the expression of MUC13 in metastatic colon cancer. Herein, we investigated the expression profile of MUC13 in colon cancer using a novel anti-MUC13 monoclonal antibody (MAb, clone ppz0020) by immunohistochemical (IHC) analysis. A cohort of colon cancer samples and tissue microarrays containing adjacent normal, non-metastatic colon cancer, metastatic colon cancer, and liver metastasis tissues was used in this study to investigate the expression pattern of MUC13. IHC analysis revealed significantly higher (p<0.001) MUC13 expression in non-metastatic colon cancer samples compared with faint or very low expression in adjacent normal tissues. Interestingly, metastatic colon cancer and liver metastasis tissue samples demonstrated significantly (p<0.05) higher cytoplasmic and nuclear MUC13 expression compared with non-metastatic colon cancer and adjacent normal colon samples. Moreover, cytoplasmic and nuclear MUC13 expression correlated with larger and poorly differentiated tumors. Four of six tested colon cancer cell lines also expressed MUC13 at RNA and protein levels. These studies demonstrate a significant increase in MUC13 expression in metastatic colon cancer and suggest a correlation between aberrant MUC13 localization (cytoplasmic and nuclear expression) and metastatic colon cancer.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22914648      PMCID： PMC3524568          DOI： 10.1369/0022155412460678

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  17 in total

1.  Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells.

Authors:  S J Williams; D H Wreschner; M Tran; H J Eyre; G R Sutherland; M A McGuckin
Journal:  J Biol Chem       Date:  2001-02-26       Impact factor: 5.157

Review 2.  A genetic model for colorectal tumorigenesis.

Authors:  E R Fearon; B Vogelstein
Journal:  Cell       Date:  1990-06-01       Impact factor: 41.582

3.  Overexpression of MUC13 is associated with intestinal-type gastric cancer.

Authors:  Takahiro Shimamura; Hirotaka Ito; Junji Shibahara; Akira Watanabe; Yoshitaka Hippo; Hirokazu Taniguchi; Yongxin Chen; Takeshi Kashima; Toshihiko Ohtomo; Fumihiko Tanioka; Hiroko Iwanari; Tatsuhiko Kodama; Teruhisa Kazui; Haruhiko Sugimura; Masashi Fukayama; Hiroyuki Aburatani
Journal:  Cancer Sci       Date:  2005-05       Impact factor: 6.716

4.  Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths.

Authors:  Rebecca Siegel; Elizabeth Ward; Otis Brawley; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2011-06-17       Impact factor: 508.702

Review 5.  Mucin 13: structure, function, and potential roles in cancer pathogenesis.

Authors:  Diane M Maher; Brij K Gupta; Satoshi Nagata; Meena Jaggi; Subhash C Chauhan
Journal:  Mol Cancer Res       Date:  2011-03-30       Impact factor: 5.852

6.  Classification of human colorectal adenocarcinoma cell lines.

Authors:  A Leibovitz; J C Stinson; W B McCombs; C E McCoy; K C Mazur; N D Mabry
Journal:  Cancer Res       Date:  1976-12       Impact factor: 12.701

7.  MUC13 mucin augments pancreatic tumorigenesis.

Authors:  Subhash C Chauhan; Mara C Ebeling; Diane M Maher; Michael D Koch; Akira Watanabe; Hiroyuki Aburatani; Yuhlong Lio; Meena Jaggi
Journal:  Mol Cancer Ther       Date:  2011-10-25       Impact factor: 6.261

8.  Expression of the cell surface mucin gene family in adenocarcinomas.

Authors:  Leisl M Packer; Stephanie J Williams; Shirley Callaghan; David C Gotley; Michael A McGuckin
Journal:  Int J Oncol       Date:  2004-10       Impact factor: 5.650

9.  Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis.

Authors:  Ajay P Singh; Nicolas Moniaux; Subhash C Chauhan; Jane L Meza; Surinder K Batra
Journal:  Cancer Res       Date:  2004-01-15       Impact factor: 12.701

10.  The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells.

Authors:  Heather C Workman; Jamie K Miller; Ellen Q Ingalla; Rouminder P Kaur; Diane I Yamamoto; Laurel A Beckett; Lawrence Jt Young; Robert D Cardiff; Alexander D Borowsky; Kermit L Carraway; Colleen Sweeney; Kermit L Carraway
Journal:  Breast Cancer Res       Date:  2009       Impact factor: 6.466
View more
  20 in total

1.  Up-regulation of collagen proteins in colorectal liver metastasis compared with normal liver tissue.

Authors:  Nick A van Huizen; Robert R J Coebergh van den Braak; Michael Doukas; Lennard J M Dekker; Jan N M IJzermans; Theo M Luider
Journal:  J Biol Chem       Date:  2018-11-08       Impact factor: 5.157

2.  Biophysical changes caused by altered MUC13 expression in pancreatic cancer cells.

Authors:  Andrew E Massey; Kyle A Doxtater; Murali M Yallapu; Subhash C Chauhan
Journal:  Micron       Date:  2020-01-03       Impact factor: 2.251

Review 3.  Mucins in pancreatic cancer and its microenvironment.

Authors:  Sukhwinder Kaur; Sushil Kumar; Navneet Momi; Aaron R Sasson; Surinder K Batra
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2013-07-16       Impact factor: 46.802

4.  Colonic transcriptional response to 1α,25(OH)2 vitamin D3 in African- and European-Americans.

Authors:  Dereck Alleyne; David B Witonsky; Brandon Mapes; Shigeki Nakagome; Meredith Sommars; Ellie Hong; Katy A Muckala; Anna Di Rienzo; Sonia S Kupfer
Journal:  J Steroid Biochem Mol Biol       Date:  2017-02-03       Impact factor: 4.292

Review 5.  Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.

Authors:  Jos P M van Putten; Karin Strijbis
Journal:  J Innate Immun       Date:  2017-01-05       Impact factor: 7.349

6.  Functions and regulation of MUC13 mucin in colon cancer cells.

Authors:  Brij K Gupta; Diane M Maher; Mara C Ebeling; Phillip D Stephenson; Susan E Puumala; Michael R Koch; Hiroyuki Aburatani; Meena Jaggi; Subhash C Chauhan
Journal:  J Gastroenterol       Date:  2013-10-07       Impact factor: 7.527

7.  Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.

Authors:  Nandini A Sahasrabuddhe; Mustafa A Barbhuiya; Shushruta Bhunia; Tejaswini Subbannayya; Harsha Gowda; Jayshree Advani; Braj R Shrivastav; Sanjay Navani; Pamela Leal; Juan Carlos Roa; Raghothama Chaerkady; Sanjeev Gupta; Aditi Chatterjee; Akhilesh Pandey; Pramod K Tiwari
Journal:  Biochem Biophys Res Commun       Date:  2014-03-20       Impact factor: 3.575

8.  Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice.

Authors:  Liyuan Li; Maoxiang Qian; I-Hsuan Chen; David Finkelstein; Arzu Onar-Thomas; Melissa Johnson; Christopher Calabrese; Armita Bahrami; Dolores H López-Terrada; Jun J Yang; W Andy Tao; Liqin Zhu
Journal:  Am J Pathol       Date:  2017-12-15       Impact factor: 4.307

Review 9.  Protein mislocalization: mechanisms, functions and clinical applications in cancer.

Authors:  Xiaohong Wang; Shulin Li
Journal:  Biochim Biophys Acta       Date:  2014-04-04

10.  Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the Multi-Ethnic Study of Atherosclerosis.

Authors:  Erin B Ware; Bhramar Mukherjee; Yan V Sun; Ana V Diez-Roux; Sharon L R Kardia; Jennifer A Smith
Journal:  BMC Genet       Date:  2015-10-12       Impact factor: 2.797
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.