Literature DB >> 24709009

Protein mislocalization: mechanisms, functions and clinical applications in cancer.

Xiaohong Wang1, Shulin Li2.   

Abstract

The changes from normal cells to cancer cells are primarily regulated by genome instability, which foster hallmark functions of cancer through multiple mechanisms including protein mislocalization. Mislocalization of these proteins, including oncoproteins, tumor suppressors, and other cancer-related proteins, can interfere with normal cellular function and cooperatively drive tumor development and metastasis. This review describes the cancer-related effects of protein subcellular mislocalization, the related mislocalization mechanisms, and the potential application of this knowledge to cancer diagnosis, prognosis, and therapy.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cancer; Oncogene; Subcellular localization; Tumor suppressor

Mesh：

Substances：

Year:  2014        PMID： 24709009      PMCID： PMC4141035          DOI： 10.1016/j.bbcan.2014.03.006

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  198 in total

Review 1.  The importance of p53 location: nuclear or cytoplasmic zip code?

Authors:  Aurora O'Brate; Paraskevi Giannakakou
Journal:  Drug Resist Updat       Date:  2003-12       Impact factor: 18.500

2.  MUC1 expression and its association with other aetiological factors and localization to mitochondria in preneoplastic and neoplastic gastric tissues.

Authors:  J B Elisha Benjamin; Venkatraman Jayanthi; Halagowder Devaraj
Journal:  Clin Chim Acta       Date:  2010-09-08       Impact factor: 3.786

3.  Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways.

Authors:  Uma Raju; Oliver Riesterer; Zhi-Qiang Wang; David P Molkentine; Jessica M Molkentine; Faye M Johnson; Bonnie Glisson; Luka Milas; K Kian Ang
Journal:  Radiother Oncol       Date:  2012-09-23       Impact factor: 6.280

4.  Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

Authors:  U M Moll; M LaQuaglia; J Bénard; G Riou
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

5.  Laryngeal carcinoma lymph node metastasis and disease-free survival correlate with MASPIN nuclear expression but not with EGFR expression: a series of 108 cases.

Authors:  Gino Marioni; Alberto Staffieri; Andy Bertolin; Luciano Giacomelli; Emiliano D'Alessandro; Giancarlo Ottaviano; Daria Accordi; Roberto Stramare; Cosimo de Filippis; Stella Blandamura
Journal:  Eur Arch Otorhinolaryngol       Date:  2010-01-06       Impact factor: 2.503

6.  Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry.

Authors:  George Deeb; Jianmin Wang; Nithya Ramnath; Harry K Slocum; Sam Wiseman; Amy Beck; Dongfeng Tan
Journal:  Mod Pathol       Date:  2004-04       Impact factor: 7.842

Review 7.  Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.

Authors:  Koji Aoki; Makoto M Taketo
Journal:  J Cell Sci       Date:  2007-10-01       Impact factor: 5.285

8.  [Immunohistochemical demonstration of mutant nucleophosmin in acute myeloid leukemia: biological and clinical features related to NPMc expression].

Authors:  Judit Bedekovics; László Rejto; Béla Telek; Miklós Udvardy; Anikó Ujfalusi; Eva Oláh; Zsuzsa Hevessy; János Kappelmayer; Béla Kajtár; Gábor Méhes
Journal:  Orv Hetil       Date:  2009-05-31       Impact factor: 0.540

9.  MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cells.

Authors:  Takeshi Kawano; Masaki Ito; Deepak Raina; Zekui Wu; Jacalyn Rosenblatt; David Avigan; Richard Stone; Donald Kufe
Journal:  Cancer Res       Date:  2007-12-15       Impact factor: 12.701

10.  Molecular ordering of hypoxia-induced apoptosis: critical involvement of the mitochondrial death pathway in a FADD/caspase-8 independent manner.

Authors:  Martin Weinmann; Verena Jendrossek; Rene Handrick; Dilek Güner; Barbara Goecke; Claus Belka
Journal:  Oncogene       Date:  2004-05-06       Impact factor: 9.867
View more
  24 in total

1.  TP53 Status and Estrogen Receptor-Beta in Triple-Negative Breast Cancer: Company Matters.

Authors:  Sunil S Badve; Yesim Gökmen-Polar
Journal:  J Natl Cancer Inst       Date:  2019-11-01       Impact factor: 13.506

Review 2.  Thyroid hormone receptor localization in target tissues.

Authors:  Cyril S Anyetei-Anum; Vincent R Roggero; Lizabeth A Allison
Journal:  J Endocrinol       Date:  2018-02-12       Impact factor: 4.286

3.  Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands.

Authors:  Elham Dianati; Isabelle Plante
Journal:  J Vis Exp       Date:  2017-05-30       Impact factor: 1.355

4.  Mislocalization of Cancer-associated Thyroid Hormone Receptor Mutants.

Authors:  Michael S Salomon; S Harshini Malapati; Jerry O' Dwyer; Carolina Lopez Silva; Cheyenne C Williams; Michelle C Barbeau; Delbert Yip; Paige Punzalan; Veronica L Nagle; Shantá D Hinton; Vincent R Roggero; Lizabeth A Allison
Journal:  Nucl Receptor Res       Date:  2020

5.  Comparison of proteolytic, cytotoxic and anticoagulant properties of chromatographically fractionated bromelain to un-fractionated bromelain.

Authors:  Samina Badar; Mohamed Azarkan; Ahmed H Mekkawy; Javed Akhter; Krishna Pillai; Rachida El Mahyaoui; Kevin Ke; Lauren Cavanaugh; David L Morris
Journal:  Am J Transl Res       Date:  2021-05-15       Impact factor: 4.060

6.  Characterization of the nuclear matrix targeting sequence (NMTS) of the BPV1 E8/E2 protein--the shortest known NMTS.

Authors:  Eve Sankovski; Kristiina Karro; Mari Sepp; Reet Kurg; Mart Ustav; Aare Abroi
Journal:  Nucleus       Date:  2015       Impact factor: 4.197

7.  Surface Expression of Kynurenine 3-Monooxygenase Promotes Proliferation and Metastasis in Triple-Negative Breast Cancers.

Authors:  Min-Hua Lai; Chi-Hsun Liao; Nu-Man Tsai; Kai-Fu Chang; Cheng-Chi Liu; Yi-Han Chiu; Kuo-Ching Huang; Chen-Si Lin
Journal:  Cancer Control       Date:  2021 Jan-Dec       Impact factor: 3.302

8.  The G-Protein-Coupled Membrane Estrogen Receptor Is Present in Horse Cryptorchid Testes and Mediates Downstream Pathways.

Authors:  Maciej Witkowski; Laura Pardyak; Piotr Pawlicki; Anna Galuszka; Magdalena Profaska-Szymik; Bartosz J Plachno; Samuel Kantor; Michal Duliban; Malgorzata Kotula-Balak
Journal:  Int J Mol Sci       Date:  2021-07-01       Impact factor: 5.923

9.  Impact of Increased FUT8 Expression on the Extracellular Vesicle Proteome in Prostate Cancer Cells.

Authors:  David J Clark; Michael Schnaubelt; Naseruddin Hoti; Yingwei Hu; Yangying Zhou; Mahta Gooya; Hui Zhang
Journal:  J Proteome Res       Date:  2020-05-18       Impact factor: 4.466

10.  A synthetic circuit for buffering gene dosage variation between individual mammalian cells.

Authors:  Jin Yang; Jihwan Lee; Michelle A Land; Shujuan Lai; Oleg A Igoshin; François St-Pierre
Journal:  Nat Commun       Date:  2021-07-05       Impact factor: 14.919
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.