Literature DB >> 22908032

Epidemiology and molecular characterization of hepatitis B virus infection in isolated villages in the Western Brazilian Amazon.

Márcia da Costa Castilho1, Cintia Mara Costa de Oliveira, João Bosco de Lima Gimaque, Jorge Di Tommaso Leão, Wornei Silva Miranda Braga.   

Abstract

Individuals from three isolated, rural communities in the western Brazilian Amazon were evaluated for serological markers of hepatitis B virus (HBV) infection, HBV genotype, and the presence of risk factors for infection and transmission. Of the 225 individuals studied, 79.1% had serological evidence of HBV infection; 10.2% individuals were chronic carriers for HBV surface antigen (HBsAg-positive). Analysis of risk factors indicates that HBV is transmitted mainly horizontally within the family from a chronic "active" carrier for hepatitis B "e" antigen (HBeAg-positive), though a strong possibility of vertical transmission remains. The predominance of HBV genotype F, with a higher genomic similarity between the isolates, indicated a relatively recent introduction of HBV, from a common source, to the area. This study sheds light on the HBV epidemiology in the Brazilian Amazon region and highlights the need for greater emphasis on HBV control and immunization programs.

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Year:  2012        PMID： 22908032      PMCID： PMC3516333          DOI： 10.4269/ajtmh.2012.12-0083

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  53 in total

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Authors:  M N dos S Moresco; H de A Virgolino; M P E de Morais; I da Motta-Passos; M S Gomes-Gouvêa; L M S de Assis; K R de L Aguiar; S C F Lombardi; A Malheiro; N de P Cavalheiro; J E Levi; K L Torres
Journal:  Vox Sang       Date:  2014-02-21       Impact factor: 2.144

4.  Phylogeography and evolutionary history of hepatitis B virus genotype F in Brazil.

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5.  The Seroprevalence of Hepatitis B in Akbar Abad Village, Kavar, Southern Iran.

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8.  Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil.

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  8 in total

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