OBJECTIVES: To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power. DESIGN: Prospective cohort. SETTING: Six U.S. academic medical centers. PARTICIPANTS: Community-dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study. MEASUREMENTS: Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two-year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants. RESULTS: Baseline serum albumin <40 g/L was not associated with 2- or 4.6-year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1-2 g/L) in serum albumin over 2 years exhibited a modest change of -8.9 W (95% CI = -25.6 to -7.8 W) and -6.3 W (95% CI = -21.2 to -8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration. CONCLUSION: Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.
OBJECTIVES: To investigate the relationship between serum albumin and change in muscle mass, grip strength, and leg power. DESIGN: Prospective cohort. SETTING: Six U.S. academic medical centers. PARTICIPANTS: Community-dwelling men aged 65 and older participating in the Osteoporotic Fractures in Men (MrOS) Study. MEASUREMENTS: Serum albumin was measured at baseline in 5,534 participants. Baseline serum albumin was examined in relation to change in appendicular skeletal muscle (ASM) mass, grip strength, and leg power after 2 and 4.6 years. Two-year change in serum albumin was examined with respect to simultaneous change in these outcomes in 1,267 participants. RESULTS: Baseline serum albumin <40 g/L was not associated with 2- or 4.6-year change in ASM mass, grip strength, or leg power before or after adjustment for confounders. There was no association between serum albumin change and change in grip strength. A statistically significant trend was observed between serum albumin change and change in ASM mass, but there was substantial overlap across confidence intervals (CIs). Participants with a marked decrease (>3 g/L) and mild decrease (1-2 g/L) in serum albumin over 2 years exhibited a modest change of -8.9 W (95% CI = -25.6 to -7.8 W) and -6.3 W (95% CI = -21.2 to -8.5 W) of leg power, respectively (P for trend = .02), compared with those with no decrease in albumin concentration. CONCLUSION:Serum albumin demonstrated modest and inconsistent trends with loss of muscle mass and function. Low serum albumin within the normal range is not a risk factor for this process in elderly men.
Authors: Marjolein Visser; Stephen B Kritchevsky; Anne B Newman; Bret H Goodpaster; Frances A Tylavsky; Michael C Nevitt; Tamara B Harris Journal: Am J Clin Nutr Date: 2005-09 Impact factor: 7.045
Authors: Eric Orwoll; Janet Babich Blank; Elizabeth Barrett-Connor; Jane Cauley; Steven Cummings; Kristine Ensrud; Cora Lewis; Peggy M Cawthon; Robert Marcus; Lynn M Marshall; Joan McGowan; Kathy Phipps; Sherry Sherman; Marcia L Stefanick; Katie Stone Journal: Contemp Clin Trials Date: 2005-10 Impact factor: 2.226
Authors: L P Fried; R A Kronmal; A B Newman; D E Bild; M B Mittelmark; J F Polak; J A Robbins; J M Gardin Journal: JAMA Date: 1998-02-25 Impact factor: 56.272
Authors: D Gallagher; M Visser; R E De Meersman; D Sepúlveda; R N Baumgartner; R N Pierson; T Harris; S B Heymsfield Journal: J Appl Physiol (1985) Date: 1997-07
Authors: Marjolein Visser; Bret H Goodpaster; Stephen B Kritchevsky; Anne B Newman; Michael Nevitt; Susan M Rubin; Eleanor M Simonsick; Tamara B Harris Journal: J Gerontol A Biol Sci Med Sci Date: 2005-03 Impact factor: 6.053
Authors: Bianca W M Schalk; Dorly J H Deeg; Brenda W J H Penninx; Lex M Bouter; Marjolein Visser Journal: J Am Geriatr Soc Date: 2005-08 Impact factor: 5.562
Authors: E M Reijnierse; M C Trappenburg; M J Leter; S Sipilä; L Stenroth; M V Narici; J Y Hogrel; G Butler-Browne; J S McPhee; M Pääsuke; H Gapeyeva; C G M Meskers; A B Maier Journal: Age (Dordr) Date: 2015-08-27