| Literature DB >> 22903763 |
Victor S M Braga1, Taiza P Mancilha, Ricardo J Cassella, Wagner F Pacheco.
Abstract
Statins are a class of drugs mostly used for treating hyperlipidemia, and rosuvastatin is the newest drug in the market belonging to this class. In this present work, a method was developed based on the molecular fluorescence technique, with the objective to quantify rosuvastatin in urine samples. For this purpose, the study of several parameters was made to achieve the maximum analytical signal (under reaction with sulfuric acid during 40 min). Also, a previous step to avoid matrix interference was carried out (liquid-liquid extraction). The limit of detection (LOD) and the limit of quantification (LOQ) were 0.38 and 1.28 mg L(-1), respectively. Linear relationship between rosuvastatin concentration and it's fluorescence intensity was found until 5.0 mg L(-1). The proposed method was tested in several samples spiked with rosuvastatin and recovery was found in the range of 90 ± 10%.Entities:
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Year: 2012 PMID： 22903763 DOI： 10.1007/s10895-012-1115-4
Source DB: PubMed Journal: J Fluoresc ISSN： 1053-0509 Impact factor: 2.217