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Literature DB >> 22903230

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils.

Sewoon Han¹, Ji-Jing Yan, Yoojin Shin, Jessie J Jeon, Jihee Won, Hyo Eun Jeong, Roger D Kamm, Young-Joon Kim, Seok Chung.

Abstract

Spatiotemporal analysis of the inflammatory response has been limited by the difficulties of in vivo imaging and reconstitution of inflammation in vitro. Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process. This enabled us to concurrently characterize transendothelial migration behaviors of neutrophils under the influence of various inflammatory stimuli.

Entities: Disease

Mesh：

Year: 2012 PMID： 22903230 DOI： 10.1039/c2lc40445a

Source DB: PubMed Journal: Lab Chip ISSN： 1473-0189 Impact factor: 6.799

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Cited

31 in total

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils.

1. Hydrophobic Patterning-Based 3D Microfluidic Cell Culture Assay.

Review 2. Physical influences of the extracellular environment on cell migration.

3. A dual-docking microfluidic cell migration assay (D²-Chip) for testing neutrophil chemotaxis and the memory effect.

4. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa.

5. Microfluidic organs-on-chips.

Review 6. Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics.

Review 7. Addressing Patient Specificity in the Engineering of Tumor Models.

Review 8. Engineered Microvessels for the Study of Human Disease.

Review 9. A human-on-a-chip approach to tackling rare diseases.

Review 10. Inflammation-on-a-Chip: Probing the Immune System Ex Vivo.

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils.

1. Hydrophobic Patterning-Based 3D Microfluidic Cell Culture Assay.

Review 2. Physical influences of the extracellular environment on cell migration.

3. A dual-docking microfluidic cell migration assay (D2-Chip) for testing neutrophil chemotaxis and the memory effect.

4. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa.

5. Microfluidic organs-on-chips.

Review 6. Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics.

Review 7. Addressing Patient Specificity in the Engineering of Tumor Models.

Review 8. Engineered Microvessels for the Study of Human Disease.

Review 9. A human-on-a-chip approach to tackling rare diseases.

Review 10. Inflammation-on-a-Chip: Probing the Immune System Ex Vivo.

3. A dual-docking microfluidic cell migration assay (D²-Chip) for testing neutrophil chemotaxis and the memory effect.