Literature DB >> 22898884

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity.

Valentina D'Atri1, Giorgia Oliviero, Jussara Amato, Nicola Borbone, Stefano D'Errico, Luciano Mayol, Vincenzo Piccialli, Shozeb Haider, Bart Hoorelbeke, Jan Balzarini, Gennaro Piccialli.   

Abstract

This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.

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Year:  2012        PMID： 22898884     DOI： 10.1039/c2cc34399a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation.

Authors:  Chang-Jun Li; Peng Cheng; Meng-Ke Liang; Yu-Si Chen; Qiong Lu; Jin-Yu Wang; Zhu-Ying Xia; Hou-De Zhou; Xu Cao; Hui Xie; Er-Yuan Liao; Xiang-Hang Luo
Journal:  J Clin Invest       Date:  2015-03-09       Impact factor: 14.808

Review 2.  Use of Aptamers as Diagnostics Tools and Antiviral Agents for Human Viruses.

Authors:  Víctor M González; M Elena Martín; Gerónimo Fernández; Ana García-Sacristán
Journal:  Pharmaceuticals (Basel)       Date:  2016-12-16

3.  5-Amino-1-(2',3'-O-iso-propyl-idene-d-ribit-yl)-1H-imidazole-4-carboxamide: a crystal structure with Z' = 4.

Authors:  Vincenzo Piccialli; Nicola Borbone; Giorgia Oliviero; Gennaro Piccialli; Stefano D'Errico; Roberto Centore
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-01-13

4.  Self-Assembly of G-Rich Oligonucleotides Incorporating a 3'-3' Inversion of Polarity Site: A New Route Towards G-Wire DNA Nanostructures.

Authors:  Giorgia Oliviero; Stefano D'Errico; Brunella Pinto; Fabrizia Nici; Principia Dardano; Ilaria Rea; Luca De Stefano; Luciano Mayol; Gennaro Piccialli; Nicola Borbone
Journal:  ChemistryOpen       Date:  2017-06-13       Impact factor: 2.911

Review 5.  G-quadruplex-based aptamers against protein targets in therapy and diagnostics.

Authors:  Chiara Platella; Claudia Riccardi; Daniela Montesarchio; Giovanni N Roviello; Domenica Musumeci
Journal:  Biochim Biophys Acta Gen Subj       Date:  2016-11-16       Impact factor: 3.770

Review 6.  Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition.

Authors:  Claudia Riccardi; Ettore Napolitano; Domenica Musumeci; Daniela Montesarchio
Journal:  Molecules       Date:  2020-11-10       Impact factor: 4.411

Review 7.  Aptamers in Virology-A Consolidated Review of the Most Recent Advancements in Diagnosis and Therapy.

Authors:  Tejabhiram Yadavalli; Ipsita Volety; Deepak Shukla
Journal:  Pharmaceutics       Date:  2021-10-09       Impact factor: 6.321

8.  Protein Binding of Benzofuran Derivatives: A CD Spectroscopic and In Silico Comparative Study of the Effects of 4-Nitrophenyl Functionalized Benzofurans and Benzodifurans on BSA Protein Structure.

Authors:  Pasqualina Liana Scognamiglio; Caterina Vicidomini; Francesco Fontanella; Claudio De Stefano; Rosanna Palumbo; Giovanni N Roviello
Journal:  Biomolecules       Date:  2022-02-05

9.  Crystal structure of an ep-oxy-sterol: 9α,11α-ep-oxy-5α-cholest-7-ene-3β,5,6α-triol 3,6-di-acetate.

Authors:  Vincenzo Piccialli; Angela Tuzi; Roberto Centore
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-10-06

10.  Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation.

Authors:  Daniela Marasco; Caterina Vicidomini; Pawel Krupa; Federica Cioffi; Pham Dinh Quoc Huy; Mai Suan Li; Daniele Florio; Kerensa Broersen; Maria Francesca De Pandis; Giovanni N Roviello
Journal:  Chem Biol Interact       Date:  2020-10-22       Impact factor: 5.192
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