| Literature DB >> 22892047 |
X F Zhang1, S Mansouri, D A Mbeh, L'H Yahia, E Sacher, T Veres.
Abstract
We report the synthesis of Fe(3)O(4)/silica core/shell nanoparticles and their functionalization with S-nitrosothiols. These nanoparticles are of immense interest because of their nitric oxide (NO) release capabilities in human alveolar epithelial cells. Moreover, they act as large storage reservoirs of NO that can be targeted magnetically to the specific site with a sustainable release of NO for up to 50 h. Such nanoparticles provide an enhancement of the biocompatibility with released NO while allowing intracellular accumulation ascribed to their small size.Entities:
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Year: 2012 PMID: 22892047 DOI: 10.1021/la302357h
Source DB: PubMed Journal: Langmuir ISSN: 0743-7463 Impact factor: 3.882