AIMS/HYPOTHESIS: Sedentary (sitting) behaviours are ubiquitous in modern society. We conducted a systematic review and meta-analysis to examine the association of sedentary time with diabetes, cardiovascular disease and cardiovascular and all-cause mortality. METHODS: Medline, Embase and the Cochrane Library databases were searched for terms related to sedentary time and health outcomes. Cross-sectional and prospective studies were included. RR/HR and 95% CIs were extracted by two independent reviewers. Data were adjusted for baseline event rate and pooled using a random-effects model. Bayesian predictive effects and intervals were calculated to indicate the variance in outcomes that would be expected if new studies were conducted in the future. RESULTS: Eighteen studies (16 prospective, two cross-sectional) were included, with 794,577 participants. Fifteen of these studies were moderate to high quality. The greatest sedentary time compared with the lowest was associated with a 112% increase in the RR of diabetes (RR 2.12; 95% credible interval [CrI] 1.61, 2.78), a 147% increase in the RR of cardiovascular events (RR 2.47; 95% CI 1.44, 4.24), a 90% increase in the risk of cardiovascular mortality (HR 1.90; 95% CrI 1.36, 2.66) and a 49% increase in the risk of all-cause mortality (HR 1.49; 95% CrI 1.14, 2.03). The predictive effects and intervals were only significant for diabetes. CONCLUSIONS/ INTERPRETATION: Sedentary time is associated with an increased risk of diabetes, cardiovascular disease and cardiovascular and all-cause mortality; the strength of the association is most consistent for diabetes.
AIMS/HYPOTHESIS: Sedentary (sitting) behaviours are ubiquitous in modern society. We conducted a systematic review and meta-analysis to examine the association of sedentary time with diabetes, cardiovascular disease and cardiovascular and all-cause mortality. METHODS: Medline, Embase and the Cochrane Library databases were searched for terms related to sedentary time and health outcomes. Cross-sectional and prospective studies were included. RR/HR and 95% CIs were extracted by two independent reviewers. Data were adjusted for baseline event rate and pooled using a random-effects model. Bayesian predictive effects and intervals were calculated to indicate the variance in outcomes that would be expected if new studies were conducted in the future. RESULTS: Eighteen studies (16 prospective, two cross-sectional) were included, with 794,577 participants. Fifteen of these studies were moderate to high quality. The greatest sedentary time compared with the lowest was associated with a 112% increase in the RR of diabetes (RR 2.12; 95% credible interval [CrI] 1.61, 2.78), a 147% increase in the RR of cardiovascular events (RR 2.47; 95% CI 1.44, 4.24), a 90% increase in the risk of cardiovascular mortality (HR 1.90; 95% CrI 1.36, 2.66) and a 49% increase in the risk of all-cause mortality (HR 1.49; 95% CrI 1.14, 2.03). The predictive effects and intervals were only significant for diabetes. CONCLUSIONS/ INTERPRETATION: Sedentary time is associated with an increased risk of diabetes, cardiovascular disease and cardiovascular and all-cause mortality; the strength of the association is most consistent for diabetes.
Authors: Tatiana Y Warren; Vaughn Barry; Steven P Hooker; Xuemei Sui; Timothy S Church; Steven N Blair Journal: Med Sci Sports Exerc Date: 2010-05 Impact factor: 5.411
Authors: David W Dunstan; Jo Salmon; Neville Owen; Timothy Armstrong; Paul Z Zimmet; Timothy A Welborn; Adrian J Cameron; Terence Dwyer; Damien Jolley; Jonathan E Shaw Journal: Diabetes Care Date: 2004-11 Impact factor: 19.112
Authors: Jonathan A C Sterne; Alex J Sutton; John P A Ioannidis; Norma Terrin; David R Jones; Joseph Lau; James Carpenter; Gerta Rücker; Roger M Harbord; Christopher H Schmid; Jennifer Tetzlaff; Jonathan J Deeks; Jaime Peters; Petra Macaskill; Guido Schwarzer; Sue Duval; Douglas G Altman; David Moher; Julian P T Higgins Journal: BMJ Date: 2011-07-22
Authors: D W Dunstan; E L M Barr; G N Healy; J Salmon; J E Shaw; B Balkau; D J Magliano; A J Cameron; P Z Zimmet; N Owen Journal: Circulation Date: 2010-01-11 Impact factor: 29.690
Authors: Robert V Same; David I Feldman; Nishant Shah; Seth S Martin; Mahmoud Al Rifai; Michael J Blaha; Garth Graham; Haitham M Ahmed Journal: Curr Cardiol Rep Date: 2016-01 Impact factor: 2.931
Authors: Christine A Pellegrini; Sara A Hoffman; Elyse R Daly; Manuel Murillo; Gleb Iakovlev; Bonnie Spring Journal: Transl Behav Med Date: 2015-09 Impact factor: 3.046
Authors: Steven T Johnson; Brigid Lynch; Jeff Vallance; Margie H Davenport; Paul A Gardiner; Sonia Butalia Journal: Endocrine Date: 2016-01-28 Impact factor: 3.633
Authors: Julianne D van der Berg; Hans Bosma; Paolo Caserotti; Gudny Eiriksdottir; Nanna Yr Arnardottir; Kathryn R Martin; Robert J Brychta; Kong Y Chen; Thorarinn Sveinsson; Erlingur Johannsson; Lenore J Launer; Vilmundur Gudnason; Palmi V Jonsson; Coen D A Stehouwer; Tamara B Harris; Annemarie Koster Journal: Med Sci Sports Exerc Date: 2014-07 Impact factor: 5.411
Authors: John Bellettiere; Genevieve N Healy; Michael J LaMonte; Jacqueline Kerr; Kelly R Evenson; Eileen Rillamas-Sun; Chongzhi Di; David M Buchner; Melbourne F Hovell; Andrea Z LaCroix Journal: J Gerontol A Biol Sci Med Sci Date: 2019-02-15 Impact factor: 6.053
Authors: J Henson; T Yates; S J H Biddle; C L Edwardson; K Khunti; E G Wilmot; L J Gray; T Gorely; M A Nimmo; M J Davies Journal: Diabetologia Date: 2013-03-01 Impact factor: 10.122
Authors: Paddy C Dempsey; Jennifer M Blankenship; Robyn N Larsen; Julian W Sacre; Parneet Sethi; Nora E Straznicky; Neale D Cohen; Ester Cerin; Gavin W Lambert; Neville Owen; Bronwyn A Kingwell; David W Dunstan Journal: Diabetologia Date: 2016-12-09 Impact factor: 10.122