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Literature DB >> 22890609

Profiling of substrates for zinc-dependent lysine deacylase enzymes: HDAC3 exhibits decrotonylase activity in vitro.

Abstract

Systematic screening of the activities of the eleven human zinc-dependent lysine deacylases against a series of fluorogenic substrates as well as kinetic evaluation revealed substrates for screenings of histone deacetylases HDAC10 and HDAC11 at reasonably low enzyme concentrations. Furthermore, HDAC3 in complex with nuclear receptor corepressor 1 (HDAC3-NCoR1) was shown to harbor decrotonylase activity in vitro.

Entities: Gene Species

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Year: 2012 PMID： 22890609 DOI： 10.1002/anie.201203754

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

32 in total

Review 1. Histones: at the crossroads of peptide and protein chemistry.

Authors: Manuel M Müller; Tom W Muir
Journal: Chem Rev Date: 2014-10-20 Impact factor: 60.622

2. Global profiling of crotonylation on non-histone proteins.

Authors: Weizhi Xu; Junhu Wan; Jun Zhan; Xueying Li; Huiying He; Zhaomei Shi; Hongquan Zhang
Journal: Cell Res Date: 2017-04-21 Impact factor: 25.617

3. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

Authors: Wei Wei; Xiaoguang Liu; Jiwei Chen; Shennan Gao; Lu Lu; Huifang Zhang; Guangjin Ding; Zhiqiang Wang; Zhongzhou Chen; Tieliu Shi; Jiwen Li; Jianjun Yu; Jiemin Wong
Journal: Cell Res Date: 2017-05-12 Impact factor: 25.617

4. New chemical tools for probing activity and inhibition of the NAD⁺-dependent lysine deacylase sirtuin 2.

Authors: Sören Swyter; Matthias Schiedel; Daria Monaldi; Sándor Szunyogh; Attila Lehotzky; Tobias Rumpf; Judit Ovádi; Wolfgang Sippl; Manfred Jung
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2018-06-05 Impact factor: 6.237

5. Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.

Authors: Andreas S Madsen; Christian Andersen; Mohammad Daoud; Kristin A Anderson; Jonas S Laursen; Saswati Chakladar; Frank K Huynh; Ana R Colaço; Donald S Backos; Peter Fristrup; Matthew D Hirschey; Christian A Olsen
Journal: J Biol Chem Date: 2016-02-09 Impact factor: 5.157

Profiling of substrates for zinc-dependent lysine deacylase enzymes: HDAC3 exhibits decrotonylase activity in vitro.

Review 1. Histones: at the crossroads of peptide and protein chemistry.

2. Global profiling of crotonylation on non-histone proteins.

3. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

4. New chemical tools for probing activity and inhibition of the NAD⁺-dependent lysine deacylase sirtuin 2.

5. Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.

6. Novel thiourea-based sirtuin inhibitory warheads.

Review 7. Metabolic reprogramming by class I and II histone deacetylases.

Review 8. Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

Review 9. Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function.

10. Chelatable trace zinc causes low, irreproducible KDAC8 activity.

Profiling of substrates for zinc-dependent lysine deacylase enzymes: HDAC3 exhibits decrotonylase activity in vitro.

Review 1. Histones: at the crossroads of peptide and protein chemistry.

2. Global profiling of crotonylation on non-histone proteins.

3. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.

4. New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.

5. Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH.

6. Novel thiourea-based sirtuin inhibitory warheads.

Review 7. Metabolic reprogramming by class I and II histone deacetylases.

Review 8. Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases.

Review 9. Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function.

10. Chelatable trace zinc causes low, irreproducible KDAC8 activity.

4. New chemical tools for probing activity and inhibition of the NAD⁺-dependent lysine deacylase sirtuin 2.