Literature DB >> 22890315

Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis.

Xiaofeng Zhao1, Yinglin Huang, Jingying Li, Hui Ma, Qiu Jin, Yuan Wang, Lijuan Wu, Gang Zhu.   

Abstract

Previous studies have implicated 5-HT1A receptor gene (HTR1A) polymorphisms in the therapeutic response to antidepressants, especially selective serotonin reuptake inhibitors. A functional HTR1A C-1019G polymorphism (rs6295) in the promoter region was found to be associated with antidepressant pharmacogenetics in different populations. However, inconsistent and inconclusive results have been obtained. In this study, we tested whether rs6295 genetic variants are related to antidepressant effects using a meta-analysis method. The relevant literature was acquired through deliberate searching and selection based on the established inclusion criteria for publications. A total of 10 articles were identified, all of which evaluated the HTR1A C-1019G polymorphism and antidepressant response. Dominant and recessive models were tested in the analyses, and the results revealed no association between the HTR1A C-1019G polymorphism and antidepressant response.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22890315     DOI： 10.1097/YIC.0b013e32835818bf

Source DB:  PubMed          Journal:  Int Clin Psychopharmacol        ISSN： 0268-1315            Impact factor:   1.659


  9 in total

Review 1.  Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.

Authors:  Tristram A Lett; Henrik Walter; Eva J Brandl
Journal:  CNS Drugs       Date:  2016-12       Impact factor: 5.749

Review 2.  Identifying genetic loci affecting antidepressant drug response in depression using drug-gene interaction models.

Authors:  Raymond Noordam; Christy L Avery; Loes E Visser; Bruno H Stricker
Journal:  Pharmacogenomics       Date:  2016-06-01       Impact factor: 2.533

3.  HTR1A Gene Polymorphism in Type 2 Diabetes Mellitus Comorbid with Major Depressive Disorder in a Chinese Population.

Authors:  Dilixia Simayi; Yaqun Guan
Journal:  Diabetes Metab Syndr Obes       Date:  2022-05-25       Impact factor: 3.249

4.  Does the 5-HT1A rs6295 polymorphism influence the safety and efficacy of citalopram therapy in the oldest old?

Authors:  Greg Scutt; Andrew Overall; Railton Scott; Bhavik Patel; Lamia Hachoumi; Mark Yeoman; Juliet Wright
Journal:  Ther Adv Drug Saf       Date:  2018-04-23

Review 5.  Blood-based biomarkers predicting response to antidepressants.

Authors:  Yasmin Busch; Andreas Menke
Journal:  J Neural Transm (Vienna)       Date:  2018-01-27       Impact factor: 3.575

Review 6.  Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder.

Authors:  Ibrahim Mohammed Badamasi; Munn Sann Lye; Normala Ibrahim; Nurul Asyikin Abdul Razaq; King Hwa Ling; Johnson Stanslas
Journal:  Pharmacogenomics J       Date:  2021-03-17       Impact factor: 3.550

7.  A Decade of Pharmacogenetic Studies in Jordan: A Systemic Review.

Authors:  Alaa Yehya; Zaid Altaany
Journal:  Pharmacogenomics J       Date:  2021-04-13       Impact factor: 3.550

8.  A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants.

Authors:  Sofia H Kanders; Claudia Pisanu; Marcus Bandstein; Jörgen Jonsson; Enrique Castelao; Giorgio Pistis; Mehdi Gholam-Rezaee; Chin B Eap; Martin Preisig; Helgi B Schiöth; Jessica Mwinyi
Journal:  Drug Dev Res       Date:  2019-10-16       Impact factor: 4.360

Review 9.  HTR1A Polymorphisms and Clinical Efficacy of Antipsychotic Drug Treatment in Schizophrenia: A Meta-Analysis.

Authors:  Yoshiteru Takekita; Chiara Fabbri; Masaki Kato; Yosuke Koshikawa; Aran Tajika; Toshihiko Kinoshita; Alessandro Serretti
Journal:  Int J Neuropsychopharmacol       Date:  2016-04-29       Impact factor: 5.176
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.