BACKGROUND: Radiation and chemotherapy targeted to the central nervous system (CNS) can cause cognitive impairment, including impaired memory. These memory impairments may be referable to damage to hippocampal structures resulting from CNS treatment. PROCEDURE: In the present study, we explored episodic memory and its neuroimaging correlates in 10 adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation therapy and both systemic and intrathecal chemotherapy and 10 controls matched for age and sex, using a subsequent memory paradigm after episodic encoding of visual scenes. RESULTS: We report behavioral, structural, and functional changes in the brains of the adult survivors. They demonstrated poorer recognition memory, hippocampal atrophy, and altered blood oxygenation level-dependent (BOLD) signal in the hippocampus. Whole brain statistical map analysis revealed increased BOLD signal/activation in several brain regions during unsuccessful encoding in ALL survivors, potentially reflecting ineffective neural recruitment. Individual differences in memory performance in ALL participants were related to magnitude of BOLD response in regions associated with successful encoding. CONCLUSIONS: Taken together, these findings describe long term neuroimaging correlates of cognitive dysfunction after childhood exposure to CNS-targeted cancer therapies, suggesting enduring damage to episodic memory systems.
BACKGROUND:Radiation and chemotherapy targeted to the central nervous system (CNS) can cause cognitive impairment, including impaired memory. These memory impairments may be referable to damage to hippocampal structures resulting from CNS treatment. PROCEDURE: In the present study, we explored episodic memory and its neuroimaging correlates in 10 adult survivors of childhood acute lymphoblastic leukemia (ALL) treated with cranial radiation therapy and both systemic and intrathecal chemotherapy and 10 controls matched for age and sex, using a subsequent memory paradigm after episodic encoding of visual scenes. RESULTS: We report behavioral, structural, and functional changes in the brains of the adult survivors. They demonstrated poorer recognition memory, hippocampal atrophy, and altered blood oxygenation level-dependent (BOLD) signal in the hippocampus. Whole brain statistical map analysis revealed increased BOLD signal/activation in several brain regions during unsuccessful encoding in ALL survivors, potentially reflecting ineffective neural recruitment. Individual differences in memory performance in ALL participants were related to magnitude of BOLD response in regions associated with successful encoding. CONCLUSIONS: Taken together, these findings describe long term neuroimaging correlates of cognitive dysfunction after childhood exposure to CNS-targeted cancer therapies, suggesting enduring damage to episodic memory systems.
Authors: Alexandra Golby; Gerald Silverberg; Elizabeth Race; Susan Gabrieli; James O'Shea; Kyle Knierim; Glenn Stebbins; John Gabrieli Journal: Brain Date: 2005-02-10 Impact factor: 13.501
Authors: Bonnie J Nagel; Shawna L Palmer; Wilburn E Reddick; John O Glass; Kathleen J Helton; Shengjie Wu; Xiaoping Xiong; Larry E Kun; Amar Gajjar; Raymond K Mulhern Journal: AJNR Am J Neuroradiol Date: 2004-10 Impact factor: 3.825
Authors: Eunjee Lee; Hongtu Zhu; Dehan Kong; Yalin Wang; Kelly Sullivan Giovanello; Joseph G Ibrahim Journal: Ann Appl Stat Date: 2015-12 Impact factor: 2.083
Authors: Shelli R Kesler; Meike Gugel; Mika Pritchard-Berman; Clement Lee; Emily Kutner; S M Hadi Hosseini; Gary Dahl; Norman Lacayo Journal: Pediatr Blood Cancer Date: 2014-03-12 Impact factor: 3.167
Authors: Joseph Scafidi; Jonathan Ritter; Brooke M Talbot; Jorge Edwards; Li-Jin Chew; Vittorio Gallo Journal: Cancer Res Date: 2018-03-20 Impact factor: 12.701
Authors: Michelle N Edelmann; Robert J Ogg; Matthew A Scoggins; Tara M Brinkman; Noah D Sabin; Ching-Hon Pui; Deo Kumar Srivastava; Leslie L Robison; Melissa M Hudson; Kevin R Krull Journal: Pediatr Blood Cancer Date: 2013-06-18 Impact factor: 3.167