OBJECTIVE: To assess the effects of treatment for acute lymphoblastic leukemia (ALL) on children's cognitive functioning. METHOD: Participants were long-term survivors of ALL treated with cranial irradiation and central nervous system (CNS) chemotherapy (n = 20), or CNS chemotherapy only (n = 21), healthy children (n = 21), and children with chronic asthma (n = 21). The groups were compared on measures of intellectual, neuropsychological, and academic functioning. RESULTS: CNS chemotherapy, with and without cranial irradiation, was associated with significantly lower levels of intellectual and academic functioning. Children with chronic asthma obtained lower scores than healthy controls, but these differences were not significant. Tests of neuropsychological functioning did not consistently separate the groups. CONCLUSIONS: CNS chemotherapy and, to a lesser extent, chronic illness both contribute to the poorer performance of long-term survivors of ALL on measures of intellectual and academic functioning.
OBJECTIVE: To assess the effects of treatment for acute lymphoblastic leukemia (ALL) on children's cognitive functioning. METHOD:Participants were long-term survivors of ALL treated with cranial irradiation and central nervous system (CNS) chemotherapy (n = 20), or CNS chemotherapy only (n = 21), healthy children (n = 21), and children with chronic asthma (n = 21). The groups were compared on measures of intellectual, neuropsychological, and academic functioning. RESULTS: CNS chemotherapy, with and without cranial irradiation, was associated with significantly lower levels of intellectual and academic functioning. Children with chronic asthma obtained lower scores than healthy controls, but these differences were not significant. Tests of neuropsychological functioning did not consistently separate the groups. CONCLUSIONS: CNS chemotherapy and, to a lesser extent, chronic illness both contribute to the poorer performance of long-term survivors of ALL on measures of intellectual and academic functioning.
Authors: Marc H Bornstein; Sara Scrimin; Diane L Putnick; Fabia Capello; O Maurice Haynes; Simona de Falco; Modesto Carli; Marta Pillon Journal: J Pediatr Psychol Date: 2012-02-02
Authors: Wilburn E Reddick; Zuyao Y Shan; John O Glass; Susan Helton; Xiaoping Xiong; Shengjie Wu; Melanie J Bonner; Scott C Howard; Robbin Christensen; Raja B Khan; Ching-Hon Pui; Raymond K Mulhern Journal: Cancer Date: 2006-02-15 Impact factor: 6.860
Authors: Deborah P Waber; Jennifer Turek Queally; Lori Catania; Philippe Robaey; Ivonne Romero; Heather Adams; Cheryl Alyman; Christine Jandet-Brunet; Stephen E Sallan; Lewis B Silverman Journal: Pediatr Blood Cancer Date: 2011-06-30 Impact factor: 3.167
Authors: Marilyn J Hockenberry; Olga A Taylor; Patricia M Gundy; Adam K Ross; Alice Pasvogel; David Montgomery; Phillip Ribbeck; Kathy McCarthy; Ida Moore Journal: Biol Res Nurs Date: 2013-08-15 Impact factor: 2.522
Authors: Lisa S Kahalley; Heather M Conklin; Vida L Tyc; Melissa M Hudson; Stephanie J Wilson; Shengjie Wu; Xiaoping Xiong; Pamela S Hinds Journal: Psychooncology Date: 2013-02-28 Impact factor: 3.894
Authors: Michelle Monje; Moriah E Thomason; Laura Rigolo; Yalin Wang; Deborah P Waber; Stephen E Sallan; Alexandra J Golby Journal: Pediatr Blood Cancer Date: 2012-08-08 Impact factor: 3.167
Authors: Stephanie L Stenzel; Kevin R Krull; Marilyn Hockenberry; Neelam Jain; Kris Kaemingk; Petra Miketova; Ida M Moore Journal: J Pediatr Hematol Oncol Date: 2010-03 Impact factor: 1.289