| Literature DB >> 22885925 |
Yongyong Shi1, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, Zhiqiang Li, Bo Zhang, Xiaoyan Liang, Tao Li, Jianhua Chen, Jiawei Shen, Junzhao Zhao, Li You, Xuan Gao, Dongyi Zhu, Xiaoming Zhao, Ying Yan, Yingying Qin, Wenjin Li, Junhao Yan, Qingzhong Wang, Junli Zhao, Ling Geng, Jinlong Ma, Yueran Zhao, Guang He, Aiping Zhang, Shuhua Zou, Aijun Yang, Jiayin Liu, Weidong Li, Baojie Li, Chunling Wan, Ying Qin, Juanzi Shi, Jing Yang, Hong Jiang, Jin-e Xu, Xiujuan Qi, Yun Sun, Yajie Zhang, Cuifang Hao, Xiuqing Ju, Dongni Zhao, Chun-e Ren, Xiuqing Li, Wei Zhang, Yiwen Zhang, Jiangtao Zhang, Di Wu, Changming Zhang, Lin He, Zi-Jiang Chen.
Abstract
Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 × 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.Entities:
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Year: 2012 PMID： 22885925 DOI： 10.1038/ng.2384
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330