OBJECTIVE: To investigate the association between two genetic variations in the Interleukin-1 beta (IL1B) gene and preterm birth. STUDY DESIGN: In this case-control study we tested the allelic distribution of two of its common polymorphisms (IL1B +3953C>T [rs1143634], IL1B -511C>T [rs16944]) in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. RESULTS: A significant association was found between the presence of the IL1B +3953C>T polymorphism and preterm birth (p=0.049, OR 0.6 [0.3-1.0]). No significant association was found between the IL1B -511C>T polymorphism and preterm birth (p=0.471, OR 1.3 [0.7-2.3]). CONCLUSION: Our findings suggest that the IL1B +3953C>T polymorphism is associated with a risk reduction for preterm birth in Caucasian women, possibly by altering the inflammatory response during pregnancy.
OBJECTIVE: To investigate the association between two genetic variations in the Interleukin-1 beta (IL1B) gene and preterm birth. STUDY DESIGN: In this case-control study we tested the allelic distribution of two of its common polymorphisms (IL1B +3953C>T [rs1143634], IL1B -511C>T [rs16944]) in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth. RESULTS: A significant association was found between the presence of the IL1B +3953C>T polymorphism and preterm birth (p=0.049, OR 0.6 [0.3-1.0]). No significant association was found between the IL1B -511C>T polymorphism and preterm birth (p=0.471, OR 1.3 [0.7-2.3]). CONCLUSION: Our findings suggest that the IL1B +3953C>T polymorphism is associated with a risk reduction for preterm birth in Caucasian women, possibly by altering the inflammatory response during pregnancy.
Authors: Jerome F Strauss; Roberto Romero; Nardhy Gomez-Lopez; Hannah Haymond-Thornburg; Bhavi P Modi; Maria E Teves; Laurel N Pearson; Timothy P York; Harvey A Schenkein Journal: Am J Obstet Gynecol Date: 2017-12-14 Impact factor: 8.661
Authors: Ishfaq A Sheikh; Ejaz Ahmad; Mohammad S Jamal; Mohd Rehan; Mourad Assidi; Iftikhar A Tayubi; Samera F AlBasri; Osama S Bajouh; Rola F Turki; Adel M Abuzenadah; Ghazi A Damanhouri; Mohd A Beg; Mohammed Al-Qahtani Journal: BMC Genomics Date: 2016-10-17 Impact factor: 3.969
Authors: José Pacheco-Romero; Oscar Acosta; Doris Huerta; Santiago Cabrera; Marlene Vargas; Pedro Mascaro; Moisés Huamán; José Sandoval; Rudy López; Julio Mateus; Enrique Gil; Enrique Guevara; Nitza Butrica; Diana Catari; David Bellido; Gina Custodio; Andrea Naranjo Journal: Colomb Med (Cali) Date: 2021-02-26
Authors: Rashmi Manning; Catherine P James; Marie C Smith; Barbara A Innes; Elaine Stamp; Donald Peebles; Mona Bajaj-Elliott; Nigel Klein; Judith N Bulmer; Stephen C Robson; Gendie E Lash Journal: Sci Rep Date: 2019-08-02 Impact factor: 4.379