BACKGROUND: Hypoferremia is a marker of disease severity in cystic fibrosis (CF). The effect of systemic antibiotics on iron homeostasis during CF pulmonary exacerbation (CFPE) is unknown. Our central hypotheses were that, by the completion of treatment, serum iron would increase, serum concentrations of interleukin-6 (IL-6) and hepcidin-25, two mediators of hypoferremia, would decrease, and sputum iron would decrease. METHODS: Blood and sputum samples were collected from 12 subjects with moderate-to-severe CF (median percentage-predicted forced expiratory volume in 1 second (FEV(1) %) = 29%; median weight = 56 kg) within 24 hours of starting and completing a course of systemic antibiotics. RESULTS: After treatment, subjects showed median FEV(1) % and body weight improvements of 4.5% and 2.0 kg, respectively (p < 0.05). Median serum iron rose by 2.4 μmol/L (p < 0.05), but 75% of patients remained hypoferremic. Median serum IL-6 and hepcidin-25 levels fell by 12.1 pg/mL and 37.5 ng/mL, respectively (p < 0.05). Median serum erythropoietin (EPO) and hemoglobin levels were unaffected by treatment. We observed a trend toward lower sputum iron content after treatment. CONCLUSIONS: Hypoferremia is a salient characteristic of CFPE that improves with waning inflammation. Despite antibiotic treatment, many patients remain hypoferremic and anemic because of ineffective erythropoiesis.
BACKGROUND: Hypoferremia is a marker of disease severity in cystic fibrosis (CF). The effect of systemic antibiotics on iron homeostasis during CF pulmonary exacerbation (CFPE) is unknown. Our central hypotheses were that, by the completion of treatment, serum iron would increase, serum concentrations of interleukin-6 (IL-6) and hepcidin-25, two mediators of hypoferremia, would decrease, and sputum iron would decrease. METHODS: Blood and sputum samples were collected from 12 subjects with moderate-to-severe CF (median percentage-predicted forced expiratory volume in 1 second (FEV(1) %) = 29%; median weight = 56 kg) within 24 hours of starting and completing a course of systemic antibiotics. RESULTS: After treatment, subjects showed median FEV(1) % and body weight improvements of 4.5% and 2.0 kg, respectively (p < 0.05). Median serum iron rose by 2.4 μmol/L (p < 0.05), but 75% of patients remained hypoferremic. Median serum IL-6 and hepcidin-25 levels fell by 12.1 pg/mL and 37.5 ng/mL, respectively (p < 0.05). Median serum erythropoietin (EPO) and hemoglobin levels were unaffected by treatment. We observed a trend toward lower sputum iron content after treatment. CONCLUSIONS: Hypoferremia is a salient characteristic of CFPE that improves with waning inflammation. Despite antibiotic treatment, many patients remain hypoferremic and anemic because of ineffective erythropoiesis.
Authors: J Abbott; A Holt; A Hart; A M Morton; L MacDougall; M Pogson; G Milne; H C Rodgers; S P Conway Journal: J Cyst Fibros Date: 2009-08-08 Impact factor: 5.482
Authors: Paaladinesh Thavendiranathan; Akshay Bagai; Albert Ebidia; Allan S Detsky; Niteesh K Choudhry Journal: J Gen Intern Med Date: 2005-06 Impact factor: 5.128
Authors: Sophie Moreau-Marquis; Jennifer M Bomberger; Gregory G Anderson; Agnieszka Swiatecka-Urban; Siying Ye; George A O'Toole; Bruce A Stanton Journal: Am J Physiol Lung Cell Mol Physiol Date: 2008-03-21 Impact factor: 5.464
Authors: A Termoz; S Touzet; S Bourdy; E Decullier; L Bouveret; C Colin; R Nove-Josserand; P Reix; C Cracowski; I Pin; G Bellon; I Durieu Journal: Pediatr Pulmonol Date: 2008-09
Authors: Nupur K Das; Andrew J Schwartz; Gabrielle Barthel; Naohiro Inohara; Qing Liu; Amanda Sankar; David R Hill; Xiaoya Ma; Olivia Lamberg; Matthew K Schnizlein; Juan L Arqués; Jason R Spence; Gabriel Nunez; Andrew D Patterson; Duxin Sun; Vincent B Young; Yatrik M Shah Journal: Cell Metab Date: 2019-11-07 Impact factor: 27.287
Authors: Alex H Gifford; Diana M Alexandru; Zhigang Li; Dana B Dorman; Lisa A Moulton; Katherine E Price; Thomas H Hampton; Mitchell L Sogin; Jonathan B Zuckerman; H Worth Parker; Bruce A Stanton; George A O'Toole Journal: J Cyst Fibros Date: 2013-12-13 Impact factor: 5.482
Authors: Matthew R Hendricks; Lauren P Lashua; Douglas K Fischer; Becca A Flitter; Katherine M Eichinger; Joan E Durbin; Saumendra N Sarkar; Carolyn B Coyne; Kerry M Empey; Jennifer M Bomberger Journal: Proc Natl Acad Sci U S A Date: 2016-01-04 Impact factor: 11.205
Authors: Alex H Gifford; Dana B Dorman; Lisa A Moulton; Jennifer E Helm; Mary M Griffin; Todd A MacKenzie Journal: Clin Transl Sci Date: 2015-12-08 Impact factor: 4.689