BACKGROUND AND PURPOSE: Interest in the possibility that diet might help to reduce the risk of colorectal cancer dates back to 1970 based on both the large variation in rates of specific cancers in different countries and the impressive changes observed in the incidence of cancer in migrants from low- to high-risk areas. Here, we report the state of art of literature data about this topic. METHODS: Three sections have been separately considered: chemoprevention of first tumor onset, chemoprevention of recurrence after surgery, and chemoprevention of polyp recurrence in the course of the follow-up of subjects with elevated risk. A particular attention has been pointed to dietary factors and survival, whose relevance is showing a growing interest. RESULTS: The relationship between diet and colorectal cancer has been extensively studied about the onset, sometimes with controversial results. Its influence on recurrence and survival has been examined in only few studies. CONCLUSIONS: Literature data are convincing for a protective role on the onset of preneoplastic and neoplastic lesions for some foods such as fibers, vitamin A and D, folic acid, calcium, antioxidants, and promising perspectives for some substances such as phyto-estrogens. Less evidence-based data are available on the possibility to avoid the recurrence of the disease or to affect its mortality with dietary habits. Future perspectives will be directed be not only to identify new dietary style able to prevent the onset of neoplastic lesion of the colon but also to realize an effective chemoprevention.
BACKGROUND AND PURPOSE: Interest in the possibility that diet might help to reduce the risk of colorectal cancer dates back to 1970 based on both the large variation in rates of specific cancers in different countries and the impressive changes observed in the incidence of cancer in migrants from low- to high-risk areas. Here, we report the state of art of literature data about this topic. METHODS: Three sections have been separately considered: chemoprevention of first tumor onset, chemoprevention of recurrence after surgery, and chemoprevention of polyp recurrence in the course of the follow-up of subjects with elevated risk. A particular attention has been pointed to dietary factors and survival, whose relevance is showing a growing interest. RESULTS: The relationship between diet and colorectal cancer has been extensively studied about the onset, sometimes with controversial results. Its influence on recurrence and survival has been examined in only few studies. CONCLUSIONS: Literature data are convincing for a protective role on the onset of preneoplastic and neoplastic lesions for some foods such as fibers, vitamin A and D, folic acid, calcium, antioxidants, and promising perspectives for some substances such as phyto-estrogens. Less evidence-based data are available on the possibility to avoid the recurrence of the disease or to affect its mortality with dietary habits. Future perspectives will be directed be not only to identify new dietary style able to prevent the onset of neoplastic lesion of the colon but also to realize an effective chemoprevention.
Authors: Anneleen Kuijsten; Ilja C W Arts; Peter C H Hollman; Pieter van't Veer; Ellen Kampman Journal: Cancer Epidemiol Biomarkers Prev Date: 2006-06 Impact factor: 4.254
Authors: Anita Koushik; David J Hunter; Donna Spiegelman; W Lawrence Beeson; Piet A van den Brandt; Julie E Buring; Eugenia E Calle; Eunyoung Cho; Gary E Fraser; Jo L Freudenheim; Charles S Fuchs; Edward L Giovannucci; R Alexandra Goldbohm; Lisa Harnack; David R Jacobs; Ikuko Kato; Vittorio Krogh; Susanna C Larsson; Michael F Leitzmann; James R Marshall; Marjorie L McCullough; Anthony B Miller; Pirjo Pietinen; Thomas E Rohan; Arthur Schatzkin; Sabina Sieri; Mikko J Virtanen; Alicja Wolk; Anne Zeleniuch-Jacquotte; Shumin M Zhang; Stephanie A Smith-Warner Journal: J Natl Cancer Inst Date: 2007-09-25 Impact factor: 13.506
Authors: P A Konstantinopoulos; A Kominea; G Vandoros; G P Sykiotis; P Andricopoulos; I Varakis; G Sotiropoulou-Bonikou; A G Papavassiliou Journal: Eur J Cancer Date: 2003-06 Impact factor: 9.162
Authors: Joan M Lappe; Dianne Travers-Gustafson; K Michael Davies; Robert R Recker; Robert P Heaney Journal: Am J Clin Nutr Date: 2007-06 Impact factor: 7.045
Authors: Andrea Iannone; Giuseppe Losurdo; Maria Pricci; Bruna Girardi; Antonio Massaro; Mariabeatrice Principi; Michele Barone; Enzo Ierardi; Alfredo Di Leo Journal: J Gastrointest Cancer Date: 2016-06
Authors: Stacey Meeker; Audrey Seamons; Jisun Paik; Piper M Treuting; Thea Brabb; William M Grady; Lillian Maggio-Price Journal: Cancer Res Date: 2014-06-17 Impact factor: 12.701
Authors: Erik S Blomain; Jieru E Lin; Crystal L Kraft; Urszula T Trela; Justin M Rock; Amanda S Aing; Adam E Snook; Scott A Waldman Journal: Expert Rev Clin Pharmacol Date: 2013-08-24 Impact factor: 5.045
Authors: Teresa T Fung; Rutendo Kashambwa; Kaori Sato; Stephanie E Chiuve; Charles S Fuchs; Kana Wu; Edward Giovannucci; Shuji Ogino; Frank B Hu; Jeffrey A Meyerhardt Journal: PLoS One Date: 2014-12-15 Impact factor: 3.240