CONTEXT: Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. OBJECTIVE: The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring. MATERIALS AND METHODS: The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities. RESULTS: 54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.
CONTEXT: Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. OBJECTIVE: The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring. MATERIALS AND METHODS: The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities. RESULTS: 54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.
Authors: Pablo Cisternas; Antoine Louveau; Susan M Bueno; Alexis M Kalergis; Hélène Boudin; Claudia A Riedel Journal: Mol Neurobiol Date: 2015-12-19 Impact factor: 5.590
Authors: Daniela Navarro; Mayvi Alvarado; Francisco Navarrete; Manuel Giner; Maria Jesus Obregon; Jorge Manzanares; Pere Berbel Journal: Front Neuroanat Date: 2015-02-17 Impact factor: 3.856
Authors: Caroline Trumpff; Jean De Schepper; Johan Vanderfaeillie; Nathalie Vercruysse; Herman Van Oyen; Rodrigo Moreno-Reyes; Jean Tafforeau; Stefanie Vandevijvere Journal: Arch Dis Child Date: 2016-07-08 Impact factor: 3.791