Literature DB >> 25963728

Maternal Thyroxine Levels During Pregnancy and Outcomes of Cognitive Development in Children.

Pingping Wang1, Jian Gao2, Shihua Zhao3, Yong Guo4, Zengfang Wang4, Feng Qi5.   

Abstract

Though there were many studies assessing the relationship between maternal thyroxine levels during pregnancy and cognitive development in children, there was still lack of evidence for the association from a comprehensive assessment of published data. To get a more comprehensive estimate of the influence of low maternal thyroxine levels on cognitive function, a meta-analysis of prospective cohort studies was performed. Two electronic databases, MEDLINE and EMBASE, were searched for relevant prospective cohort studies. Relative risks (RR) with 95% confidence intervals (95% CI) were pooled using random-effect model of meta-analysis to assess the risk of delayed cognitive development in children. Seven prospective cohort studies with a total of 8273 mother-child pairs were included into the meta-analysis. There was obvious between-study heterogeneity in the meta-analysis (I(2) = 69.6%). Meta-analysis of using random-effect model showed that low maternal thyroxine level was significantly associated with a threefold risk of delayed cognitive development in children (random RR = 3.08, 95% CI 1.83-5.18, P < 0.001). When excluding the study with largest weight, there was no obvious between-study heterogeneity in the left studies (I(2) = 47.6%), and meta-analysis using random-effect model showed that low maternal thyroxine level was still significantly associated with increased risk of delayed cognitive development in children (random RR = 3.76, 95% CI 2.14-6.58, P < 0.001). Sensitivity analysis by omitting other studies by turns showed that there was no obvious change in the pooled risk estimates, and all pooled RRs were statistically significant. Therefore, the findings from the meta-analysis provide strong evidence for the association between maternal thyroxine levels during pregnancy and cognitive development in children. Low maternal thyroxine level is significantly associated with a threefold risk of delayed cognitive development in children.

Entities:  

Keywords:  Brain development; Cognitive function; Thyroxine levels

Mesh：

Substances：

Year:  2015        PMID： 25963728     DOI： 10.1007/s12035-015-9189-z

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  40 in total

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2.  Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex.

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Review 6.  The role of thyroid hormones for brain development and cognitive function.

Authors:  Joanne F Rovet
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7.  Maternal and umbilical cord levels of T4, FT4, TSH, TPOAb, and TgAb in term infants and neurodevelopmental outcome at 5.5 years.

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Journal:  Mol Neurobiol       Date:  2014-02-15       Impact factor: 5.590

10.  Maternal Subclinical Hypothyroidism Impairs Neurodevelopment in Rat Offspring by Inhibiting the CREB Signaling Pathway.

Authors:  Yuanyuan Zhang; Yuxin Fan; Xiaohui Yu; Xinyi Wang; Suqing Bao; Jiashu Li; Chenling Fan; Zhongyan Shan; Weiping Teng
Journal:  Mol Neurobiol       Date:  2014-09-06       Impact factor: 5.590
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  6 in total

Review 1.  Influence of maternal thyroid hormones during gestation on fetal brain development.

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2.  Association of Maternal Exposure to Childhood Abuse With Elevated Risk for Attention Deficit Hyperactivity Disorder in Offspring.

Authors:  Andrea L Roberts; Zeyan Liew; Kristen Lyall; Alberto Ascherio; Marc G Weisskopf
Journal:  Am J Epidemiol       Date:  2018-09-01       Impact factor: 4.897

3.  Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis.

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4.  A transient window of hypothyroidism alters neural progenitor cells and results in abnormal brain development.

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5.  Neonatal Thyroxine, Maternal Thyroid Function, and Cognition in Mid-childhood in a US Cohort.

Authors:  Samantha J Lain; Sheryl L Rifas-Shiman; Elizabeth N Pearce; Natasha Nassar; Emily Oken
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6.  Thyroid Function in Pregnant Women With Moderate to Severe Alcohol Consumption Is Related to Infant Developmental Outcomes.

Authors:  Kirsten A Donald; Catherine J Wedderburn; Whitney Barnett; Nadia Hoffman; Heather J Zar; Eva E Redei; Dan J Stein
Journal:  Front Endocrinol (Lausanne)       Date:  2018-06-05       Impact factor: 5.555
  6 in total

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