Literature DB >> 22877623

Synthesis, characterization and pharmacological study of 4,5-dihydropyrazolines carrying pyrimidine moiety.

Adithya Adhikari1, Balakrishna Kalluraya, Kizhakke Veedu Sujith, Kuluvar Gouthamchandra, Ravikumar Jairam, Riaz Mahmood, Ravish Sankolli.   

Abstract

A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.

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Year:  2012        PMID: 22877623     DOI: 10.1016/j.ejmech.2012.07.002

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  4 in total

1.  Octopus: a platform for the virtual high-throughput screening of a pool of compounds against a set of molecular targets.

Authors:  Eduardo Habib Bechelane Maia; Vinícius Alves Campos; Bianca Dos Reis Santos; Marina Santos Costa; Iann Gabriel Lima; Sandro J Greco; Rosy I M A Ribeiro; Felipe M Munayer; Alisson Marques da Silva; Alex Gutterres Taranto
Journal:  J Mol Model       Date:  2017-01-07       Impact factor: 1.810

2.  Synthesis and Structure-Activity Relationships of 4-Morpholino-7,8-Dihydro-5H-Thiopyrano[4,3-d]pyrimidine Derivatives Bearing Pyrazoline Scaffold.

Authors:  Qinqin Wang; Xiaojing Li; Chengyu Sun; Binliang Zhang; Pengwu Zheng; Wufu Zhu; Shan Xu
Journal:  Molecules       Date:  2017-10-31       Impact factor: 4.411

3.  Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents.

Authors:  Talavara Venkatesh; Yadav Dasharathrao Bodke; Muthipeedika Nibin Joy; Bhadrapura Lakkappa Dhananjaya; Sivaramakrishnan Venkataraman
Journal:  Iran J Pharm Res       Date:  2018       Impact factor: 1.696

4.  Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors.

Authors:  Sahar A Ali; Samir Mohamed Awad; Ahmed Mohammed Said; Shahenda Mahgoub; Heba Taha; Naglaa Mohamed Ahmed
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

  4 in total

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