Literature DB >> 22875455

Phosphodiesterases and cyclic GMP regulation in heart muscle.

Dong I Lee1, David A Kass.   

Abstract

The cyclic nucleotide cGMP and its corresponding activated kinase cGK-1 serve as a counterbalance to acute and chronic myocardial stress. cGMP hydrolysis by several members of the phosphodiesterase (PDE) superfamily, PDE1, PDE2, and PDE5, regulate this signaling in the heart. This review details new insights regarding how these PDEs modulate cGMP and cGK-1 to influence heart function and chronic stress responses, and how their inhibition may provide potential therapeutic benefits.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22875455     DOI： 10.1152/physiol.00011.2012

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  21 in total

Review 1.  Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.

Authors:  Sanjiv J Shah; Dalane W Kitzman; Barry A Borlaug; Loek van Heerebeek; Michael R Zile; David A Kass; Walter J Paulus
Journal:  Circulation       Date:  2016-07-05       Impact factor: 29.690

Review 2.  Cyclic AMP synthesis and hydrolysis in the normal and failing heart.

Authors:  Aziz Guellich; Hind Mehel; Rodolphe Fischmeister
Journal:  Pflugers Arch       Date:  2014-04-24       Impact factor: 3.657

Review 3.  Role of sGC-dependent NO signalling and myocardial infarction risk.

Authors:  Jana Wobst; Thorsten Kessler; Tan An Dang; Jeanette Erdmann; Heribert Schunkert
Journal:  J Mol Med (Berl)       Date:  2015-03-04       Impact factor: 4.599

4.  PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.

Authors:  Walter E Knight; Si Chen; Yishuai Zhang; Masayoshi Oikawa; Meiping Wu; Qian Zhou; Clint L Miller; Yujun Cai; Deanne M Mickelsen; Christine Moravec; Eric M Small; Junichi Abe; Chen Yan
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-20       Impact factor: 11.205

5.  Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival.

Authors:  Yishuai Zhang; Walter Knight; Si Chen; Amy Mohan; Chen Yan
Journal:  Circulation       Date:  2018-10-30       Impact factor: 29.690

6.  Right ventricular cyclic nucleotide signaling is decreased in hyperoxia-induced pulmonary hypertension in neonatal mice.

Authors:  Rachel P Heilman; Megan B Lagoski; Keng Jin Lee; Joann M Taylor; Gina A Kim; Sara K Berkelhamer; Robin H Steinhorn; Kathryn N Farrow
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-04-10       Impact factor: 4.733

Review 7.  Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).

Authors:  Valentina Sala; Jean Piero Margaria; Alessandra Murabito; Fulvio Morello; Alessandra Ghigo; Emilio Hirsch
Journal:  Curr Heart Fail Rep       Date:  2017-06

Review 8.  Treatment-related biomarkers in pulmonary hypertension.

Authors:  Aparna C Swaminathan; Alex C Dusek; Tim J McMahon
Journal:  Am J Respir Cell Mol Biol       Date:  2015-06       Impact factor: 6.914

9.  Genetically altered mutant mouse models of guanylyl cyclase/natriuretic peptide receptor-A exhibit the cardiac expression of proinflammatory mediators in a gene-dose-dependent manner.

Authors:  Elangovan Vellaichamy; Subhankar Das; Umadevi Subramanian; Nobuyo Maeda; Kailash N Pandey
Journal:  Endocrinology       Date:  2014-01-01       Impact factor: 4.736

10.  Sex, drugs, and trial design: sex influences the heart and drug responses.

Authors:  Elizabeth Murphy; Charles Steenbergen
Journal:  J Clin Invest       Date:  2014-05-16       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.