Literature DB >> 22874871

Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.

Stefano D'Errico1, Giorgia Oliviero, Jussara Amato, Nicola Borbone, Vincenzo Cerullo, Akseli Hemminki, Vincenzo Piccialli, Sabrina Zaccaria, Luciano Mayol, Gennaro Piccialli.   

Abstract

A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.

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Year:  2012        PMID： 22874871     DOI： 10.1039/c2cc33511e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  Synthesis of cyclic N (1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells.

Authors:  Ahmed Mahal; Stefano D'Errico; Nicola Borbone; Brunella Pinto; Agnese Secondo; Valeria Costantino; Valentina Tedeschi; Giorgia Oliviero; Vincenzo Piccialli; Gennaro Piccialli
Journal:  Beilstein J Org Chem       Date:  2015-12-22       Impact factor: 2.883

2.  5-Amino-1-(2',3'-O-iso-propyl-idene-d-ribit-yl)-1H-imidazole-4-carboxamide: a crystal structure with Z' = 4.

Authors:  Vincenzo Piccialli; Nicola Borbone; Giorgia Oliviero; Gennaro Piccialli; Stefano D'Errico; Roberto Centore
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-01-13

3.  Pseudosymmetry and high Z' structures: the case of rac-(2R,2'R,5'S)-2-methyl-5'-[(1R,2R,5S,5'S)-1,4,4,5'-tetra-methyl-dihydro-3'H-3,8-dioxa-spiro-[bi-cyclo-[3.2.1]octane-2,2'-furan]-5'-yl]-3,4,1',2',3',4'-hexa-hydro-[2,2'-bi-furan]-5(2H)-one.

Authors:  Vincenzo Piccialli; Angela Tuzi; Roberto Centore
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-08-01

4.  Crystal structure of a new spiro-polytetra-hydro-furan compound with translational pseudosymmetry: rac-(2S,2'S,5'R)-2-methyl-5'-[(1R,2R,5S,5'R)-1,4,4,5'-tetra-methyl-dihydro-3'H-3,8-dioxa-spiro[bi-cyclo-[3.2.1]octane-2,2'-furan]-5'-yl]hexa-hydro[2,2'-bi-furan]-5(2H)-one.

Authors:  Vincenzo Piccialli; Angela Tuzi; Roberto Centore
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-04-28

5.  In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3.

Authors:  Mahendran Botlagunta; Bhulakshmi Kollapalli; Lavanya Kakarla; Siva Priya Gajarla; Sai Pujitha Gade; Chandra Lekha Dadi; Akhila Penumadu; Shaik Javeed
Journal:  Bioinformation       Date:  2016-10-18

6.  Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs.

Authors:  Stefano D'Errico; Nicola Borbone; Bruno Catalanotti; Agnese Secondo; Tiziana Petrozziello; Ilaria Piccialli; Anna Pannaccione; Valeria Costantino; Luciano Mayol; Gennaro Piccialli; Giorgia Oliviero
Journal:  Mar Drugs       Date:  2018-03-10       Impact factor: 5.118

7.  A facile synthesis of 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR): a novel non-phosphorylable AICAR analogue.

Authors:  Stefano D'Errico; Giorgia Oliviero; Nicola Borbone; Jussara Amato; Daniele D'Alonzo; Vincenzo Piccialli; Luciano Mayol; Gennaro Piccialli
Journal:  Molecules       Date:  2012-11-02       Impact factor: 4.411

Review 8.  From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides.

Authors:  Pasqualina Liana Scognamiglio; Chiara Platella; Ettore Napolitano; Domenica Musumeci; Giovanni Nicola Roviello
Journal:  Molecules       Date:  2021-06-10       Impact factor: 4.927

9.  Crystal structure of an ep-oxy-sterol: 9α,11α-ep-oxy-5α-cholest-7-ene-3β,5,6α-triol 3,6-di-acetate.

Authors:  Vincenzo Piccialli; Angela Tuzi; Roberto Centore
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-10-06

10.  Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.

Authors:  Stefano D'Errico; Giorgia Oliviero; Nicola Borbone; Jussara Amato; Vincenzo Piccialli; Michela Varra; Luciano Mayol; Gennaro Piccialli
Journal:  Molecules       Date:  2013-08-06       Impact factor: 4.411
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