Literature DB >> 22871994

Nrf2: a potential target for new therapeutics in liver disease.

A M Bataille1, J E Manautou.   

Abstract

Nuclear erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases-nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury-and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.

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Year:  2012        PMID： 22871994      PMCID： PMC3704160          DOI： 10.1038/clpt.2012.110

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  74 in total

1.  Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.

Authors:  R Venugopal; A K Jaiswal
Journal:  Oncogene       Date:  1998-12-17       Impact factor: 9.867

Review 2.  The involvement of oxidative stress in the progression of renal injury.

Authors:  E Haugen; K A Nath
Journal:  Blood Purif       Date:  1999       Impact factor: 2.614

3.  High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.

Authors:  A Enomoto; K Itoh; E Nagayoshi; J Haruta; T Kimura; T O'Connor; T Harada; M Yamamoto
Journal:  Toxicol Sci       Date:  2001-01       Impact factor: 4.849

4.  Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene.

Authors:  Valeska Vollrath; Ana M Wielandt; Mirentxu Iruretagoyena; Jose Chianale
Journal:  Biochem J       Date:  2006-05-01       Impact factor: 3.857

5.  An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

Authors:  K Itoh; T Chiba; S Takahashi; T Ishii; K Igarashi; Y Katoh; T Oyake; N Hayashi; K Satoh; I Hatayama; M Yamamoto; Y Nabeshima
Journal:  Biochem Biophys Res Commun       Date:  1997-07-18       Impact factor: 3.575

6.  Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent.

Authors:  Gianluca Svegliati-Baroni; Yutaka Inagaki; Ana-Rosa Rincon-Sanchez; Cindy Else; Stefania Saccomanno; Antonio Benedetti; Francesco Ramirez; Marcos Rojkind
Journal:  Hepatology       Date:  2005-08       Impact factor: 17.425

7.  NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.

Authors:  K Chan; R Lu; J C Chang; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

8.  Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.

Authors:  Kalpana Velmurugan; Jawed Alam; Joe M McCord; Subbiah Pugazhenthi
Journal:  Free Radic Biol Med       Date:  2008-11-17       Impact factor: 7.376

9.  Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.

Authors:  Jonathan M Maher; Matthew Z Dieter; Lauren M Aleksunes; Angela L Slitt; Grace Guo; Yuji Tanaka; George L Scheffer; Jefferson Y Chan; Jose E Manautou; Ying Chen; Timothy P Dalton; Masayuki Yamamoto; Curtis D Klaassen
Journal:  Hepatology       Date:  2007-11       Impact factor: 17.425

10.  Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics.

Authors:  C Girre; D Lucas; E Hispard; C Menez; S Dally; J F Menez
Journal:  Biochem Pharmacol       Date:  1994-04-29       Impact factor: 5.858
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  58 in total

1.  S-allylmercaptocysteine improves nonalcoholic steatohepatitis by enhancing AHR/NRF2-mediated drug metabolising enzymes and reducing NF-κB/IκBα and NLRP3/6-mediated inflammation.

Authors:  Qian Yu; Yann-Yin Lee; Zheng-Yun Xia; Emily C Liong; Jia Xiao; George L Tipoe
Journal:  Eur J Nutr       Date:  2020-06-17       Impact factor: 5.614

Review 2.  NRF2 and the Hallmarks of Cancer.

Authors:  Montserrat Rojo de la Vega; Eli Chapman; Donna D Zhang
Journal:  Cancer Cell       Date:  2018-05-03       Impact factor: 31.743

3.  Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection).

Authors:  Meeghan A O'Connor; Petra Koza-Taylor; Sarah N Campion; Lauren M Aleksunes; Xinsheng Gu; Ahmed E Enayetallah; Michael P Lawton; José E Manautou
Journal:  Toxicol Appl Pharmacol       Date:  2013-10-11       Impact factor: 4.219

Review 4.  Effects of red wine on postprandial stress: potential implication in non-alcoholic fatty liver disease development.

Authors:  Ilaria Peluso; Husseen Manafikhi; Raffaella Reggi; Maura Palmery
Journal:  Eur J Nutr       Date:  2015-03-16       Impact factor: 5.614

5.  Nrf2 participates in regulating maternal hepatic adaptations to pregnancy.

Authors:  Yuhong Zou; Min Hu; Qi Bao; Jefferson Y Chan; Guoli Dai
Journal:  J Cell Sci       Date:  2013-02-15       Impact factor: 5.285

6.  c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway.

Authors:  Maria Pina Mollica; Giovanna Trinchese; Gina Cavaliere; Chiara De Filippo; Ennio Cocca; Marcello Gaita; Antonio Della-Gatta; Angela Marano; Giuseppe Mazzarella; Paolo Bergamo
Journal:  J Lipid Res       Date:  2014-03-15       Impact factor: 5.922

Review 7.  Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease.

Authors:  Ning Zhao; Fang-Fang Guo; Ke-Qin Xie; Tao Zeng
Journal:  Cell Mol Life Sci       Date:  2018-06-11       Impact factor: 9.261

8.  Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway.

Authors:  Yimeng Zhang; Xufeng Tao; Lianhong Yin; Lina Xu; Youwei Xu; Yan Qi; Xu Han; Shasha Song; Yanyan Zhao; Yuan Lin; Kexin Liu; Jinyong Peng
Journal:  Br J Pharmacol       Date:  2017-07-05       Impact factor: 8.739

9.  Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species.

Authors:  Yongke Lu; Arthur I Cederbaum
Journal:  React Oxyg Species (Apex)       Date:  2016-03

Review 10.  Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

Authors:  Swetha Rudraiah; Xi Zhang; Li Wang
Journal:  Annu Rev Pharmacol Toxicol       Date:  2016       Impact factor: 13.820
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