| Literature DB >> 22871386 |
Jeroen Middelbeek1, Arthur J Kuipers, Linda Henneman, Daan Visser, Ilse Eidhof, Remco van Horssen, Bé Wieringa, Sander V Canisius, Wilbert Zwart, Lodewyk F Wessels, Fred C G J Sweep, Peter Bult, Paul N Span, Frank N van Leeuwen, Kees Jalink.
Abstract
TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outcome in breast cancer patients and that it is functionally required for metastasis formation in a mouse xenograft model of human breast cancer. Mechanistic investigation revealed that TRPM7 regulated myosin II-based cellular tension, thereby modifying focal adhesion number, cell-cell adhesion and polarized cell movement. Our findings therefore suggest that TRPM7 is part of a mechanosensory complex adopted by cancer cells to drive metastasis formation. ©2012 AACR.Entities:
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Year: 2012 PMID： 22871386 DOI： 10.1158/0008-5472.CAN-11-3863
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701