Evaluation of renal blood flow using multi-phase echo-planar magnetic resonance imaging and signal targeting with alternating radiofrequency (EPISTAR) in 3-T magnetic resonance imaging.

Most arterial spin labeling techniques apply the constant post-labeling delay time after the blood-labeling time point on the target artery. As the hemodynamic status cannot be estimated in each patient, quantitative values of the blood flow may not be accurate. To overcome this problem, we performed renal perfusion imaging of human kidneys using multi-phase echo-planar magnetic resonance imaging and signal targeting with an alternating radiofrequency (EPISTAR) sequence at 3-T magnetic resonance imaging. Multi-phase EPISTAR obtained 17 phases every 100 ms between 250 and 1850 ms from the arterial-labeling time point. The highest signal-intensity image obtained using multi-phase images was applied to renal blood flow (RBF) calculations. In five healthy volunteers, the mean cortical RBF was 286.6 ± 48.7 mL/100 g/min. This value was not significantly different from those in four previous studies. This technique was more useful than previous studies, in that multi-phase images could confirm the hemodynamic status on RBF calculations.