BACKGROUND: Gallstone disease is a frequent and economically highly relevant disorder, with cholecystectomy representing one of the most frequently performed operations world-wide. Gallstone recurrence after cholecystectomy is associated with complications such as biliary sepsis and pancreatitis. As yet, variant ABCG8-D19H is the most widely recognized genetic risk factor for gallstone disease. The aim of the study is to investigate whether ABCG8-D19H is associated with gallstone recurrence after cholecystectomy. METHODS: Two thousand three hundred and eight patients from an earlier study of gallstone risk factors were re-contacted by mail, leading to 1,915 patients with available clinical and genetic information. Symptomatic gallstone recurrence was established if it occurred more than six months after surgery. Median follow-up time after cholecystectomy was eight years. RESULTS: Gallstones recurred in 37 patients (1.9%). ABCG-D19H was found to be significantly associated with gallstone recurrence (p = 0.034). The allelic odds ratio was 1.97 (95% CI 1.12-∞). In a multivariate logistic regression analysis adjusted for age, sex, BMI and type of surgery, ABCG8-D19H remained a significant predictor, both in the total cohort (p = 0.024) and in the subgroup for whom information on type and scheduling of surgery was available (N = 1,650, p = 0.020). CONCLUSIONS: ABCG8-D19H is a predictor of gallstone recurrence, a major long term postoperative biliary complication. Moreover, the observed association also reemphasizes the importance of the sterolin transporter for stone formation.
BACKGROUND:Gallstone disease is a frequent and economically highly relevant disorder, with cholecystectomy representing one of the most frequently performed operations world-wide. Gallstone recurrence after cholecystectomy is associated with complications such as biliary sepsis and pancreatitis. As yet, variant ABCG8-D19H is the most widely recognized genetic risk factor for gallstone disease. The aim of the study is to investigate whether ABCG8-D19H is associated with gallstone recurrence after cholecystectomy. METHODS: Two thousand three hundred and eight patients from an earlier study of gallstone risk factors were re-contacted by mail, leading to 1,915 patients with available clinical and genetic information. Symptomatic gallstone recurrence was established if it occurred more than six months after surgery. Median follow-up time after cholecystectomy was eight years. RESULTS:Gallstones recurred in 37 patients (1.9%). ABCG-D19H was found to be significantly associated with gallstone recurrence (p = 0.034). The allelic odds ratio was 1.97 (95% CI 1.12-∞). In a multivariate logistic regression analysis adjusted for age, sex, BMI and type of surgery, ABCG8-D19H remained a significant predictor, both in the total cohort (p = 0.024) and in the subgroup for whom information on type and scheduling of surgery was available (N = 1,650, p = 0.020). CONCLUSIONS:ABCG8-D19H is a predictor of gallstone recurrence, a major long term postoperative biliary complication. Moreover, the observed association also reemphasizes the importance of the sterolin transporter for stone formation.
Authors: Oscar Lao; Timothy T Lu; Michael Nothnagel; Olaf Junge; Sandra Freitag-Wolf; Amke Caliebe; Miroslava Balascakova; Jaume Bertranpetit; Laurence A Bindoff; David Comas; Gunilla Holmlund; Anastasia Kouvatsi; Milan Macek; Isabelle Mollet; Walther Parson; Jukka Palo; Rafal Ploski; Antti Sajantila; Adriano Tagliabracci; Ulrik Gether; Thomas Werge; Fernando Rivadeneira; Albert Hofman; André G Uitterlinden; Christian Gieger; Heinz-Erich Wichmann; Andreas Rüther; Stefan Schreiber; Christian Becker; Peter Nürnberg; Matthew R Nelson; Michael Krawczak; Manfred Kayser Journal: Curr Biol Date: 2008-08-07 Impact factor: 10.834
Authors: Robert S Sandler; James E Everhart; Mark Donowitz; Elizabeth Adams; Kelly Cronin; Clifford Goodman; Eric Gemmen; Shefali Shah; Aida Avdic; Robert Rubin Journal: Gastroenterology Date: 2002-05 Impact factor: 22.682
Authors: Stephan Buch; Clemens Schafmayer; Henry Völzke; Marcus Seeger; Juan F Miquel; Silvia C Sookoian; Jan H Egberts; Alexander Arlt; Carlos J Pirola; Markus M Lerch; Ulrich John; Andre Franke; Oliver von Kampen; Mario Brosch; Michael Nothnagel; Wolfgang Kratzer; Bernhard O Boehm; Dieter C Bröring; Stefan Schreiber; Michael Krawczak; Jochen Hampe Journal: Gastroenterology Date: 2010-09-15 Impact factor: 22.682
Authors: Clemens Schafmayer; Jürgen Hartleb; Jürgen Tepel; Stefan Albers; Sandra Freitag; Henry Völzke; Stephan Buch; Markus Seeger; Birgit Timm; Bernd Kremer; Ulrich R Fölsch; Fred Fändrich; Michael Krawczak; Stefan Schreiber; Jochen Hampe Journal: BMC Gastroenterol Date: 2006-11-22 Impact factor: 3.067