Literature DB >> 22866150

Carbon and iron ion radiation-induced cytotoxicity and transformation in vitro.

Zhaozong Zhou1, Jeffrey H Ware, Ann R Kennedy.   

Abstract

The present study was undertaken to characterize carbon and iron ion radiation-induced adverse biological effects in terms of toxicity and transformation in vitro. HTori-3 human thyroid epithelial cells were irradiated with 0.3-GeV/n (13.6 KeV/µm) carbon ions and 1-GeV/n (150 KeV/µm) iron ions, both of which represent high-mass, high atomic number (Z) and high-energy particles known as HZE particles, as well as γ-rays. The survival of the irradiated cells was determined by a clonogenic survival assay. The yield of colonies growing in soft agar was used as a surrogate endpoint biomarker for transformation in vitro. The results showed that HZE particles and γ-ray radiations are effective in increasing the yield of anchorage-independent colonies. Based on the relative biological effectiveness (RBE) values in the clonogenic survival assays, 0.3-GeV/n carbon ions and 1-GeV/n iron ions were 2.9 and 2.4 times, respectively, as effective as γ-rays at killing the irradiated HTori-3 cells. At a dose of 200 cGy, 0.3-GeV/n carbon ions and 1-GeV/n iron ions were found to be 3.5 and 7.3 times, respectively, as effective as γ-rays at inducing anchorage-independent growth. These results suggest that the carcinogenic potential of 0.3-GeV/n carbon ions, as represented by the ability to induce anchorage-independent growth, may be lower than that of 1-GeV/n iron ions.

Entities:  

Year:  2011        PMID: 22866150      PMCID: PMC3408038          DOI: 10.3892/ol.2011.342

Source DB:  PubMed          Journal:  Oncol Lett        ISSN: 1792-1074            Impact factor:   2.967


  15 in total

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Authors:  Ann R Kennedy; Zhaozong Zhou; Jeremiah J Donahue; Jeffrey H Ware
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Authors:  Christine E Hellweg; Christa Baumstark-Khan
Journal:  Naturwissenschaften       Date:  2007-01-19
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  2 in total

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2.  Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation.

Authors:  Hyun Soon Bang; Moo Hyun Choi; Cha Soon Kim; Seung Jin Choi
Journal:  J Radiat Res       Date:  2016-03-22       Impact factor: 2.724

  2 in total

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