BACKGROUND: We recently described the Mycobacterium tuberculosis RD(Rio) genotype, a clonally derived sublineage within the Latin American-Mediterranean (LAM) family. Genetic diversity of M. tuberculosis likely affects the clinical aspects of tuberculosis (TB). Prospective studies that address this issue are scarce and remain controversial. OBJECTIVE: To determine the association of differential clinical features of pulmonary TB with the RD(Rio) M. tuberculosis etiology. METHODS: Culture-proven pulmonary TB patients (n = 272) were clinically evaluated, including history, physical examination, chest X-ray and anti-human immunodeficiency virus serology. Isolates were classified as RD(Rio) or non-RD(Rio) M. tuberculosis by multiplex polymerase chain reaction and further spoligotyped. Clinical and M. tuberculosis genotype data were analyzed. RESULTS: RD(Rio) M. tuberculosis caused disease in 26.5% (72/270) of all TB cases. The LAM genotype, of which RD(Rio) strains are members, was responsible for 46.0% of the TB cases. Demographic data, major signs and symptoms, radiographic presentation, microbiological features and clinical outcomes were not significantly different among patients with TB caused by RD(Rio) and non-RD(Rio) strains. CONCLUSIONS: Disease caused by M. tuberculosis RD(Rio) strains was not clinically distinctive or more severe than disease caused by non-RD(Rio) strains in this series of TB patients. Larger prospective studies specifically designed to disclose differential clinical characteristics of TB caused by specific M. tuberculosis lineages are needed.
BACKGROUND: We recently described the Mycobacterium tuberculosis RD(Rio) genotype, a clonally derived sublineage within the Latin American-Mediterranean (LAM) family. Genetic diversity of M. tuberculosis likely affects the clinical aspects of tuberculosis (TB). Prospective studies that address this issue are scarce and remain controversial. OBJECTIVE: To determine the association of differential clinical features of pulmonary TB with the RD(Rio) M. tuberculosis etiology. METHODS: Culture-proven pulmonary TBpatients (n = 272) were clinically evaluated, including history, physical examination, chest X-ray and anti-human immunodeficiency virus serology. Isolates were classified as RD(Rio) or non-RD(Rio) M. tuberculosis by multiplex polymerase chain reaction and further spoligotyped. Clinical and M. tuberculosis genotype data were analyzed. RESULTS: RD(Rio) M. tuberculosis caused disease in 26.5% (72/270) of all TB cases. The LAM genotype, of which RD(Rio) strains are members, was responsible for 46.0% of the TB cases. Demographic data, major signs and symptoms, radiographic presentation, microbiological features and clinical outcomes were not significantly different among patients with TB caused by RD(Rio) and non-RD(Rio) strains. CONCLUSIONS: Disease caused by M. tuberculosis RD(Rio) strains was not clinically distinctive or more severe than disease caused by non-RD(Rio) strains in this series of TB patients. Larger prospective studies specifically designed to disclose differential clinical characteristics of TB caused by specific M. tuberculosis lineages are needed.
Authors: T Kubica; R Agzamova; A Wright; M A Aziz; G Rakishev; V Bismilda; E Richter; S Rüsch-Gerdes; S Niemann Journal: Int J Tuberc Lung Dis Date: 2005-06 Impact factor: 2.373
Authors: Freda Maree; Anneke C Hesseling; H Simon Schaaf; Ben J Marais; Nulda Beyers; Paul van Helden; Robin M Warren; Johan F Schoeman Journal: Pediatr Infect Dis J Date: 2007-01 Impact factor: 2.129
Authors: Luiz Claudio Oliveira Lazzarini; Richard C Huard; Neio L Boechat; Harrison M Gomes; Maranibia C Oelemann; Natalia Kurepina; Elena Shashkina; Fernanda C Q Mello; Andrea L Gibson; Milena J Virginio; Ana Grazia Marsico; W Ray Butler; Barry N Kreiswirth; Philip N Suffys; Jose Roberto Lapa E Silva; John L Ho Journal: J Clin Microbiol Date: 2007-09-26 Impact factor: 5.948
Authors: Andrea L Gibson; Richard C Huard; Nicolaas C Gey van Pittius; Luiz Claudio Oliveira Lazzarini; Jeffrey Driscoll; Natalia Kurepina; Thierry Zozio; Christophe Sola; Silvana Miranda Spindola; Afrânio L Kritski; Daniel Fitzgerald; Kristin Kremer; Helmi Mardassi; Poonam Chitale; Jessica Brinkworth; Dario Garcia de Viedma; Brigitte Gicquel; Jean W Pape; Dick van Soolingen; Barry N Kreiswirth; Robin M Warren; Paul D van Helden; Nalin Rastogi; Philip N Suffys; Jose Lapa e Silva; John L Ho Journal: J Clin Microbiol Date: 2008-01-30 Impact factor: 5.948
Authors: Luiz Claudio Oliveira Lazzarini; Silvana Miranda Spindola; Heejung Bang; Andrea L Gibson; Scott Weisenberg; Wania da Silva Carvalho; Claudio José Augusto; Richard C Huard; Afrânio L Kritski; John L Ho Journal: J Clin Microbiol Date: 2008-05-07 Impact factor: 5.948
Authors: Karine Brudey; Jeffrey R Driscoll; Leen Rigouts; Wolfgang M Prodinger; Andrea Gori; Sahal A Al-Hajoj; Caroline Allix; Liselotte Aristimuño; Jyoti Arora; Viesturs Baumanis; Lothar Binder; Patricia Cafrune; Angel Cataldi; Soonfatt Cheong; Roland Diel; Christopher Ellermeier; Jason T Evans; Maryse Fauville-Dufaux; Séverine Ferdinand; Dario Garcia de Viedma; Carlo Garzelli; Lidia Gazzola; Harrison M Gomes; M Cristina Guttierez; Peter M Hawkey; Paul D van Helden; Gurujaj V Kadival; Barry N Kreiswirth; Kristin Kremer; Milan Kubin; Savita P Kulkarni; Benjamin Liens; Troels Lillebaek; Minh Ly Ho; Carlos Martin; Christian Martin; Igor Mokrousov; Olga Narvskaïa; Yun Fong Ngeow; Ludmilla Naumann; Stefan Niemann; Ida Parwati; Zeaur Rahim; Voahangy Rasolofo-Razanamparany; Tiana Rasolonavalona; M Lucia Rossetti; Sabine Rüsch-Gerdes; Anna Sajduda; Sofia Samper; Igor G Shemyakin; Urvashi B Singh; Akos Somoskovi; Robin A Skuce; Dick van Soolingen; Elisabeth M Streicher; Philip N Suffys; Enrico Tortoli; Tatjana Tracevska; Véronique Vincent; Tommie C Victor; Robin M Warren; Sook Fan Yap; Khadiza Zaman; Françoise Portaels; Nalin Rastogi; Christophe Sola Journal: BMC Microbiol Date: 2006-03-06 Impact factor: 3.605
Authors: R S Salvato; S Schiefelbein; R B Barcellos; B M Praetzel; I S Anusca; L S Esteves; M L Halon; G Unis; C F Dias; S S Miranda; I N de Almeida; L J de Assis Figueredo; E C Silva; A L Kritski; E R Dalla Costa; M L R Rossetti Journal: Epidemiol Infect Date: 2019-01 Impact factor: 2.451
Authors: Eloise Brasil Moraes; Letícia Slompo; Amanda Juliane Finardi; Heloisa Paro Pedro da Silveira; Luciana Ruiz; Harrison Magdinier Gomes; Virginia Bodelão Richini; Philip Suffys; Carlos Magno Castelo Branco Fortaleza; Ricardo Cavalcanti; Ida Maria Foschiani Dias Baptista Journal: Mem Inst Oswaldo Cruz Date: 2017-02-16 Impact factor: 2.743
Authors: Daniela Munro-Rojas; Esdras Fernandez-Morales; José Zarrabal-Meza; Ma Teresa Martínez-Cazares; Aurora Parissi-Crivelli; Javier Fuentes-Domínguez; Marie Nancy Séraphin; Michael Lauzardo; Jorge Alberto González-Y-Merchand; Sandra Rivera-Gutierrez; Roberto Zenteno-Cuevas Journal: PLoS One Date: 2018-03-15 Impact factor: 3.240