Literature DB >> 22859832

Redox control of NLRP3 inflammasome activation in health and disease.

Anna Rubartelli1.   

Abstract

Shifts in the redox balance between ROS and antioxidants regulate innate immunity at various levels. Changes in the redox microenvironment modulate the activation potential of the NLRP3 inflammasome, a signaling platform that activates caspase-1, allowing the maturation of IL-1β. However, a clear definition of the underlying mechanism is missing. In this essay, I review the most-credited theories on inflammasome activation. In particular, I will focus on the redox-mediated mechanisms that regulate the assembly of NLRP3 inflammasome and discuss how aberrations in them are implicated in the pathogenesis of autoinflammatory diseases.

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Year:  2012        PMID： 22859832     DOI： 10.1189/jlb.0512265

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  53 in total

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2.  Inflammasome Activity in Non-Microbial Lung Inflammation.

Authors:  Jennifer L Ather; Rebecca A Martin; Karina Ckless; Matthew E Poynter
Journal:  J Environ Immunol Toxicol       Date:  2014-09-20

3.  Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion.

Authors:  Xiujian Xu; Liang Zhang; Xinchun Ye; Qi Hao; Tao Zhang; Guiyun Cui; Ming Yu
Journal:  Inflamm Res       Date:  2017-09-27       Impact factor: 4.575

Review 4.  Laser vaccine adjuvants. History, progress, and potential.

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Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

Review 5.  Keeping the immune system in check: a role for mitophagy.

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Journal:  Immunol Cell Biol       Date:  2014-09-30       Impact factor: 5.126

6.  Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.

Authors:  Nolan K Maier; Devorah Crown; Jie Liu; Stephen H Leppla; Mahtab Moayeri
Journal:  J Immunol       Date:  2013-12-13       Impact factor: 5.422

7.  The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.

Authors:  Nolan K Maier; Stephen H Leppla; Mahtab Moayeri
Journal:  J Immunol       Date:  2015-02-13       Impact factor: 5.422

Review 8.  Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.

Authors:  Jinah Choi; Nicole L B Corder; Bhargav Koduru; Yiyan Wang
Journal:  Free Radic Biol Med       Date:  2014-05-06       Impact factor: 7.376

Review 9.  Use of Interleukin-1 Blockers in Pericardial and Cardiovascular Diseases.

Authors:  Giacomo Emmi; Maria Letizia Urban; Massimo Imazio; Marco Gattorno; Silvia Maestroni; Giuseppe Lopalco; Luca Cantarini; Domenico Prisco; Antonio Brucato
Journal:  Curr Cardiol Rep       Date:  2018-06-14       Impact factor: 2.931

10.  NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke.

Authors:  Fan Yang; Ziying Wang; Xinbing Wei; Huirong Han; Xianfang Meng; Yan Zhang; Weichen Shi; Fengli Li; Tao Xin; Qi Pang; Fan Yi
Journal:  J Cereb Blood Flow Metab       Date:  2014-01-15       Impact factor: 6.200
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