Literature DB >> 22858243

Systems biology: personalized medicine for the future?

Rui Chen1, Michael Snyder.   

Abstract

Systems biology is actively transforming the field of modern health care from symptom-based disease diagnosis and treatment to precision medicine in which patients are treated based on their individual characteristics. Development of high-throughput technologies such as high-throughout sequencing and mass spectrometry has enabled scientists and clinicians to examine genomes, transcriptomes, proteomes, metabolomes, and other omics information in unprecedented detail. The combined 'omics' information leads to a global profiling of health and disease, and provides new approaches for personalized health monitoring and preventative medicine. In this article, we review the efforts of systems biology in personalized medicine in the past 2 years, and discuss in detail achievements and concerns, as well as highlights and hurdles for future personalized health care.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22858243      PMCID： PMC4076046          DOI： 10.1016/j.coph.2012.07.011

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  44 in total

Review 1.  Rep-Seq: uncovering the immunological repertoire through next-generation sequencing.

Authors:  Jennifer Benichou; Rotem Ben-Hamo; Yoram Louzoun; Sol Efroni
Journal:  Immunology       Date:  2012-03       Impact factor: 7.397

2.  Personal genome sequencing: current approaches and challenges.

Authors:  Michael Snyder; Jiang Du; Mark Gerstein
Journal:  Genes Dev       Date:  2010-03-01       Impact factor: 11.361

Review 3.  Dissecting the HIV-specific immune response: a systems biology approach.

Authors:  Yoav Peretz; Cheryl Cameron; Rafick-Pierre Sékaly
Journal:  Curr Opin HIV AIDS       Date:  2012-01       Impact factor: 4.283

Review 4.  Boosting signal-to-noise in complex biology: prior knowledge is power.

Authors:  Trey Ideker; Janusz Dutkowski; Leroy Hood
Journal:  Cell       Date:  2011-03-18       Impact factor: 41.582

Review 5.  Extracellular microRNA: a new source of biomarkers.

Authors:  Alton Etheridge; Inyoul Lee; Leroy Hood; David Galas; Kai Wang
Journal:  Mutat Res       Date:  2011-03-23       Impact factor: 2.433

6.  Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes.

Authors:  Keiichi Kodama; Momoko Horikoshi; Kyoko Toda; Satoru Yamada; Kazuo Hara; Junichiro Irie; Marina Sirota; Alexander A Morgan; Rong Chen; Hiroshi Ohtsu; Shiro Maeda; Takashi Kadowaki; Atul J Butte
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-12       Impact factor: 11.205

7.  A comprehensive catalogue of somatic mutations from a human cancer genome.

Authors:  Erin D Pleasance; R Keira Cheetham; Philip J Stephens; David J McBride; Sean J Humphray; Chris D Greenman; Ignacio Varela; Meng-Lay Lin; Gonzalo R Ordóñez; Graham R Bignell; Kai Ye; Julie Alipaz; Markus J Bauer; David Beare; Adam Butler; Richard J Carter; Lina Chen; Anthony J Cox; Sarah Edkins; Paula I Kokko-Gonzales; Niall A Gormley; Russell J Grocock; Christian D Haudenschild; Matthew M Hims; Terena James; Mingming Jia; Zoya Kingsbury; Catherine Leroy; John Marshall; Andrew Menzies; Laura J Mudie; Zemin Ning; Tom Royce; Ole B Schulz-Trieglaff; Anastassia Spiridou; Lucy A Stebbings; Lukasz Szajkowski; Jon Teague; David Williamson; Lynda Chin; Mark T Ross; Peter J Campbell; David R Bentley; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2009-12-16       Impact factor: 49.962

8.  Towards patient-based cancer therapeutics.

Authors:  Stuart L Schreiber; Alykhan F Shamji; Paul A Clemons; Cindy Hon; Angela N Koehler; Benito Munoz; Michelle Palmer; Andrew M Stern; Bridget K Wagner; Scott Powers; Scott W Lowe; Xuecui Guo; Alex Krasnitz; Eric T Sawey; Raffaella Sordella; Lincoln Stein; Lloyd C Trotman; Andrea Califano; Riccardo Dalla-Favera; Adolfo Ferrando; Antonio Iavarone; Laura Pasqualucci; José Silva; Brent R Stockwell; William C Hahn; Lynda Chin; Ronald A DePinho; Jesse S Boehm; Shuba Gopal; Alan Huang; David E Root; Barbara A Weir; Daniela S Gerhard; Jean Claude Zenklusen; Michael G Roth; Michael A White; John D Minna; John B MacMillan; Bruce A Posner
Journal:  Nat Biotechnol       Date:  2010-09       Impact factor: 54.908

9.  Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Authors:  Rong Chen; Erik Corona; Martin Sikora; Joel T Dudley; Alex A Morgan; Andres Moreno-Estrada; Geoffrey B Nilsen; David Ruau; Stephen E Lincoln; Carlos D Bustamante; Atul J Butte
Journal:  PLoS Genet       Date:  2012-04-12       Impact factor: 5.917

10.  A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.

Authors:  Rachael Natrajan; Alan Mackay; Maryou B Lambros; Britta Weigelt; Paul M Wilkerson; Elodie Manie; Anita Grigoriadis; Roger A'Hern; Petra van der Groep; Iwanka Kozarewa; Tatiana Popova; Odette Mariani; Samra Turaljic; Simon J Furney; Richard Marais; Daniel-Nava Rodruigues; Adriana C Flora; Patty Wai; Vidya Pawar; Simon McDade; Jason Carroll; Dominique Stoppa-Lyonnet; Andrew R Green; Ian O Ellis; Charles Swanton; Paul van Diest; Olivier Delattre; Christopher J Lord; William D Foulkes; Anne Vincent-Salomon; Alan Ashworth; Marc Henri Stern; Jorge S Reis-Filho
Journal:  J Pathol       Date:  2012-02-23       Impact factor: 7.996
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  29 in total

1.  Precision medicine and molecular imaging: new targeted approaches toward cancer therapeutic and diagnosis.

Authors:  Mojtaba Ghasemi; Iraj Nabipour; Abdolmajid Omrani; Zeinab Alipour; Majid Assadi
Journal:  Am J Nucl Med Mol Imaging       Date:  2016-11-30

2.  Reconsidering clinical pharmacology frameworks as a necessary strategy for improving the health care of patients: a systematic review.

Authors:  Davide Grisafi; Alessandro Ceschi; Gianni Sava; Veronica Avalos Clerici; Francesco Scaglione
Journal:  Eur J Clin Pharmacol       Date:  2018-07-14       Impact factor: 2.953

Review 3.  Dynamical systems approaches to personalized medicine.

Authors:  Jacob D Davis; Carla M Kumbale; Qiang Zhang; Eberhard O Voit
Journal:  Curr Opin Biotechnol       Date:  2019-04-09       Impact factor: 9.740

4.  A Review of Challenges and Opportunities in Machine Learning for Health.

Authors:  Marzyeh Ghassemi; Tristan Naumann; Peter Schulam; Andrew L Beam; Irene Y Chen; Rajesh Ranganath
Journal:  AMIA Jt Summits Transl Sci Proc       Date:  2020-05-30

Review 5.  Defining phenotypes in asthma: a step towards personalized medicine.

Authors:  Kian Fan Chung
Journal:  Drugs       Date:  2014-05       Impact factor: 9.546

Review 6.  Early diagnosis of disease using microbead array technology: A review.

Authors:  Sanam Foroutan Parsa; Atieh Vafajoo; Azin Rostami; Reza Salarian; Mohammad Rabiee; Navid Rabiee; Ghazal Rabiee; Mohammadreza Tahriri; Amir Yadegari; Daryoosh Vashaee; Lobat Tayebi; Michael R Hamblin
Journal:  Anal Chim Acta       Date:  2018-05-04       Impact factor: 6.558

7.  Using systems biology approaches to understand cardiac inflammation and extracellular matrix remodeling in the setting of myocardial infarction.

Authors:  Omid Ghasemi; Yonggang Ma; Merry L Lindsey; Yu-Fang Jin
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2014 Jan-Feb

8.  E-health beyond technology: analyzing the paradigm shift that lies beneath.

Authors:  Tania Moerenhout; Ignaas Devisch; Gustaaf C Cornelis
Journal:  Med Health Care Philos       Date:  2018-03

9.  Whole-exome sequencing identifies tetratricopeptide repeat domain 7A (TTC7A) mutations for combined immunodeficiency with intestinal atresias.

Authors:  Rui Chen; Silvia Giliani; Gaetana Lanzi; George I Mias; Silvia Lonardi; Kerry Dobbs; John Manis; Hogune Im; Jennifer E Gallagher; Douglas H Phanstiel; Ghia Euskirchen; Philippe Lacroute; Keith Bettinger; Daniele Moratto; Katja Weinacht; Davide Montin; Eleonora Gallo; Giovanna Mangili; Fulvio Porta; Lucia D Notarangelo; Stefania Pedretti; Waleed Al-Herz; Wasmi Alfahdli; Anne Marie Comeau; Russell S Traister; Sung-Yun Pai; Graziella Carella; Fabio Facchetti; Kari C Nadeau; Michael Snyder; Luigi D Notarangelo
Journal:  J Allergy Clin Immunol       Date:  2013-07-04       Impact factor: 14.290

Review 10.  Validation processes of protein biomarkers in serum--a cross platform comparison.

Authors:  Katja Köhler; Harald Seitz
Journal:  Sensors (Basel)       Date:  2012-09-18       Impact factor: 3.576
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