AIM: Matrix metalloproteinase (MMP)-14 and MMP-19 have been demonstrated to play an important role in the development of human gliomas. However, their prognostic values are not clear. The aim of this study was to investigate whether co-expression of MMP-14 and MMP-19 has prognostic relevance in human gliomas. METHODS: Immunohistochemistry and western blot were used to investigate the expression of MMP-14 and MMP-19 proteins in 128 patients with gliomas. RESULTS: The expression levels of MMP-14 and MMP-19 proteins in glioma tissues were both significantly higher (both P < 0.001) than those in non-neoplastic brain tissues according to the immunohistochemistry analysis, which was confirmed by the western blot analysis. Additionally, the overexpression of either MMP-14 or MMP-19 was significantly associated with the advanced WHO grade (both P = 0.02), the low Karnofsky performance score (KPS) (P = 0.008 and 0.01, respectively) and the poor overall survival (both P = 0.01). Moreover, the Multivariate Cox proportional-hazards regression analysis revealed that the increased expressions of MMP-14 and MMP-19 were both independent prognostic factors for poor overall survival (both P = 0.02). Furthermore, the co-expression of MMP-14 and MMP-19 was additively and more significantly (P = 0.006) associated with adverse prognosis in patients with gliomas than respective expression of MMP-14 and MMP-19. CONCLUSIONS: These findings indicated for the first time that the co-expression of MMP-14 and MMP-19 is significantly correlated with prognosis in glioma patients, suggesting that the co-expression of these proteins may be used as both an early diagnostic and independent prognostic marker.
AIM: Matrix metalloproteinase (MMP)-14 and MMP-19 have been demonstrated to play an important role in the development of humangliomas. However, their prognostic values are not clear. The aim of this study was to investigate whether co-expression of MMP-14 and MMP-19 has prognostic relevance in humangliomas. METHODS: Immunohistochemistry and western blot were used to investigate the expression of MMP-14 and MMP-19 proteins in 128 patients with gliomas. RESULTS: The expression levels of MMP-14 and MMP-19 proteins in glioma tissues were both significantly higher (both P < 0.001) than those in non-neoplastic brain tissues according to the immunohistochemistry analysis, which was confirmed by the western blot analysis. Additionally, the overexpression of either MMP-14 or MMP-19 was significantly associated with the advanced WHO grade (both P = 0.02), the low Karnofsky performance score (KPS) (P = 0.008 and 0.01, respectively) and the poor overall survival (both P = 0.01). Moreover, the Multivariate Cox proportional-hazards regression analysis revealed that the increased expressions of MMP-14 and MMP-19 were both independent prognostic factors for poor overall survival (both P = 0.02). Furthermore, the co-expression of MMP-14 and MMP-19 was additively and more significantly (P = 0.006) associated with adverse prognosis in patients with gliomas than respective expression of MMP-14 and MMP-19. CONCLUSIONS: These findings indicated for the first time that the co-expression of MMP-14 and MMP-19 is significantly correlated with prognosis in gliomapatients, suggesting that the co-expression of these proteins may be used as both an early diagnostic and independent prognostic marker.
Authors: Maud Jost; Alicia R Folgueras; Françoise Frérart; Alberto M Pendas; Silvia Blacher; Xavier Houard; Sarah Berndt; Carine Munaut; Didier Cataldo; Jesus Alvarez; Laurence Melen-Lamalle; Jean-Michel Foidart; Carlos López-Otín; Agnès Noël Journal: Cancer Res Date: 2006-05-15 Impact factor: 12.701
Authors: G Murphy; V Knäuper; S Cowell; R Hembry; H Stanton; G Butler; J Freije; A M Pendás; C López-Otín Journal: Ann N Y Acad Sci Date: 1999-06-30 Impact factor: 5.691
Authors: Jelena Stojic; Carsten Hagemann; Stefanie Haas; Christian Herbold; Siglinde Kühnel; Stefanie Gerngras; Wolfgang Roggendorf; Klaus Roosen; Giles Hamilton Vince Journal: Neurosci Res Date: 2007-09-29 Impact factor: 3.304
Authors: N Velinov; D Aebersold; N Haeni; R Hlushchuk; G Mishev; F Weinstein; R Sedlacek; V Djonov Journal: Int J Biol Markers Date: 2007 Oct-Dec Impact factor: 2.659
Authors: Jan Hrabeta; Tomas Eckschlager; Marie Stiborova; Zbynek Heger; Sona Krizkova; Vojtech Adam Journal: J Mol Med (Berl) Date: 2016-09-16 Impact factor: 4.599
Authors: Benjamin B Kasten; Ke Jiang; Denzel Cole; Aditi Jani; Neha Udayakumar; G Yancey Gillespie; Guolan Lu; Tingting Dai; Eben L Rosenthal; James M Markert; Jianghong Rao; Jason M Warram Journal: Eur J Nucl Med Mol Imaging Date: 2019-11-26 Impact factor: 9.236