BACKGROUND: Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor. AIM: The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer. METHODS: Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients. RESULTS: MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren's classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression. CONCLUSIONS: The present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.
BACKGROUND:Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor. AIM: The present study aimed to investigate the association of MMP-14 with overall survival in humangastric cancer. METHODS:Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients. RESULTS:MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren's classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression. CONCLUSIONS: The present study confirmed the over-expression of MMP-14 in humangastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.
Authors: Seth B Krantz; Mario A Shields; Surabhi Dangi-Garimella; Eric C Cheon; Morgan R Barron; Rosa F Hwang; M Sambasiva Rao; Paul J Grippo; David J Bentrem; Hidayatullah G Munshi Journal: Mol Cancer Res Date: 2011-08-19 Impact factor: 5.852
Authors: Bernard Têtu; Jacques Brisson; Chang Shu Wang; Hélène Lapointe; Geneviève Beaudry; Caty Blanchette; Dominique Trudel Journal: Breast Cancer Res Date: 2006-06-15 Impact factor: 6.466