OBJECTIVE: To study whether magnetic resonance imaging can predict the histologic type of small renal cell carcinoma. METHODS: Dynamic contrast-enhanced magnetic resonance imaging was performed in 63 patients with computed tomography- or ultrasonography-suspected small (≤ 4 cm) renal cell carcinoma from February 2008 to February 2010. Percentage signal intensity change, tumor-to-cortex enhancement index during precontrast phase, corticomedullary phase, and nephrogenic phase were investigated. RESULTS: Among the 60 patients, 42 were proven to have clear cell renal cell carcinoma and 18 patients were proven to have non-clear cell renal cell carcinoma (10 patients with papillary renal cell carcinoma, 8 patients with chromophobe renal cell carcinoma). The percentage signal intensity change in the clear cell type was higher only in the corticomedullary phase (P = .002). The tumor-to-cortex enhancement index in the clear cell type was higher in the corticomedullary and nephrogenic phases (P = .007 and P = .041, respectively). The most valuable marker was percentage signal intensity change in the corticomedullary phase (area under the receiver operating characteristic curve 0.85). The cut-off value of percentage signal intensity change in the corticomedullary phase was 173%, and the sensitivity and specificity were 81% and 87.5%, respectively. CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging could be useful for discriminating the clear cell type from non-clear cell type in small renal cell carcinoma with high sensitivity and specificity.
OBJECTIVE: To study whether magnetic resonance imaging can predict the histologic type of small renal cell carcinoma. METHODS: Dynamic contrast-enhanced magnetic resonance imaging was performed in 63 patients with computed tomography- or ultrasonography-suspected small (≤ 4 cm) renal cell carcinoma from February 2008 to February 2010. Percentage signal intensity change, tumor-to-cortex enhancement index during precontrast phase, corticomedullary phase, and nephrogenic phase were investigated. RESULTS: Among the 60 patients, 42 were proven to have clear cell renal cell carcinoma and 18 patients were proven to have non-clear cell renal cell carcinoma (10 patients with papillary renal cell carcinoma, 8 patients with chromophobe renal cell carcinoma). The percentage signal intensity change in the clear cell type was higher only in the corticomedullary phase (P = .002). The tumor-to-cortex enhancement index in the clear cell type was higher in the corticomedullary and nephrogenic phases (P = .007 and P = .041, respectively). The most valuable marker was percentage signal intensity change in the corticomedullary phase (area under the receiver operating characteristic curve 0.85). The cut-off value of percentage signal intensity change in the corticomedullary phase was 173%, and the sensitivity and specificity were 81% and 87.5%, respectively. CONCLUSION: Dynamic contrast-enhanced magnetic resonance imaging could be useful for discriminating the clear cell type from non-clear cell type in small renal cell carcinoma with high sensitivity and specificity.
Authors: Jae Heon Kim; Shufeng Li; Yash Khandwala; Francesco Del Giudice; Kyung Jin Chung; Hyung Keun Park; Benjamin I Chung Journal: Can Urol Assoc J Date: 2018-08-30 Impact factor: 1.862
Authors: Andreas M Hötker; Yousef Mazaheri; Andreas Wibmer; Christoph A Karlo; Junting Zheng; Chaya S Moskowitz; Satish K Tickoo; Paul Russo; Hedvig Hricak; Oguz Akin Journal: AJR Am J Roentgenol Date: 2017-01-17 Impact factor: 3.959
Authors: Sabina Sevcenco; Martin Krssak; Domagoj Javor; Lothar Ponhold; Franklin E Kuehhas; Harun Fajkovic; Andrea Haitel; Sharokh F Shariat; Pascal A Baltzer Journal: World J Urol Date: 2014-03-09 Impact factor: 4.226
Authors: S Sevcenco; L Ponhold; D Javor; F E Kuehhas; J Mauermann; A Miernik; M Schoenthaler; P A Baltzer Journal: World J Urol Date: 2013-10-09 Impact factor: 4.226