Tracy L Rupp1, Nancy J Wesensten, Thomas J Balkin. 1. Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Abstract
OBJECTIVE: To determine the extent to which individual differences in vulnerability to total sleep deprivation also reflect individual differences in vulnerability to multiple nights of sleep restriction. DESIGN: Two sleep loss conditions (order counterbalanced) separated by 2 to 4 weeks: (a) total sleep deprivation (TSD) of 2 nights (63 h continuous wakefulness); (b) sleep restriction (SR) of 7 nights of 3 h nightly time in bed (TIB). Both conditions were preceded by 7 in-laboratory nights with 10 h nightly TIB; and followed by 3 recovery nights with 8 h nightly TIB. Measures of cognitive performance (psychomotor vigilance, working memory [1-Back], and mathematical processing), objective alertness, subjective sleepiness, and mood were obtained at regular intervals under both conditions. Intra-class correlation coefficients (ICC) were computed using outcome metrics averaged over the last day (08:00-20:00) of TSD and SR. SETTING: Residential sleep/performance testing facility. PARTICIPANTS: Nineteen healthy adults (ages 18-39; 11 males, 8 females). INTERVENTIONS: 2 nights of TSD and 7 nights SR (3 h nightly TIB). RESULTS: volunteers who displayed greater vulnerability to TSD displayed greater vulnerability to SR on cognitive performance tasks (ICC: PVT lapses = 0.89; PVT speed = 0.86; 1-Back = 0.88; mathematical processing = 0.68, Ps < 0.05). In addition, trait-like responsivity to TSD/SR was found for mood variables vigor (ICC = 0.91), fatigue (ICC = 0.73), and happiness (ICC = 0.85) (all Ps < 0.05). CONCLUSION: Resilience to sleep loss is a trait-like characteristic that reflects an individual's ability to maintain performance during both types of sleep loss (SR and TSD). Whether the findings extend to sleep schedules other than those investigated here (63 h of TSD and 7 nights of 3 h nightly TIB) will be the focus of future studies.
OBJECTIVE: To determine the extent to which individual differences in vulnerability to total sleep deprivation also reflect individual differences in vulnerability to multiple nights of sleep restriction. DESIGN: Two sleep loss conditions (order counterbalanced) separated by 2 to 4 weeks: (a) total sleep deprivation (TSD) of 2 nights (63 h continuous wakefulness); (b) sleep restriction (SR) of 7 nights of 3 h nightly time in bed (TIB). Both conditions were preceded by 7 in-laboratory nights with 10 h nightly TIB; and followed by 3 recovery nights with 8 h nightly TIB. Measures of cognitive performance (psychomotor vigilance, working memory [1-Back], and mathematical processing), objective alertness, subjective sleepiness, and mood were obtained at regular intervals under both conditions. Intra-class correlation coefficients (ICC) were computed using outcome metrics averaged over the last day (08:00-20:00) of TSD and SR. SETTING: Residential sleep/performance testing facility. PARTICIPANTS: Nineteen healthy adults (ages 18-39; 11 males, 8 females). INTERVENTIONS: 2 nights of TSD and 7 nights SR (3 h nightly TIB). RESULTS: volunteers who displayed greater vulnerability to TSD displayed greater vulnerability to SR on cognitive performance tasks (ICC: PVT lapses = 0.89; PVT speed = 0.86; 1-Back = 0.88; mathematical processing = 0.68, Ps < 0.05). In addition, trait-like responsivity to TSD/SR was found for mood variables vigor (ICC = 0.91), fatigue (ICC = 0.73), and happiness (ICC = 0.85) (all Ps < 0.05). CONCLUSION: Resilience to sleep loss is a trait-like characteristic that reflects an individual's ability to maintain performance during both types of sleep loss (SR and TSD). Whether the findings extend to sleep schedules other than those investigated here (63 h of TSD and 7 nights of 3 h nightly TIB) will be the focus of future studies.
Authors: Gregory Belenky; Nancy J Wesensten; David R Thorne; Maria L Thomas; Helen C Sing; Daniel P Redmond; Michael B Russo; Thomas J Balkin Journal: J Sleep Res Date: 2003-03 Impact factor: 3.981
Authors: Rachel Leproult; Egidio F Colecchia; Anna Maria Berardi; Robert Stickgold; Stephen M Kosslyn; Eve Van Cauter Journal: Am J Physiol Regul Integr Comp Physiol Date: 2003-02 Impact factor: 3.619
Authors: Peter McCauley; Leonid V Kalachev; Amber D Smith; Gregory Belenky; David F Dinges; Hans P A Van Dongen Journal: J Theor Biol Date: 2008-10-02 Impact factor: 2.691
Authors: Daniel Neu; Hendrik Kajosch; Philippe Peigneux; Paul Verbanck; Paul Linkowski; Olivier Le Bon Journal: Psychiatry Res Date: 2010-12-31 Impact factor: 3.222
Authors: Sridhar Ramakrishnan; Nancy J Wesensten; Gary H Kamimori; James E Moon; Thomas J Balkin; Jaques Reifman Journal: Sleep Date: 2016-10-01 Impact factor: 5.849
Authors: Adam J Krause; Eti Ben Simon; Bryce A Mander; Stephanie M Greer; Jared M Saletin; Andrea N Goldstein-Piekarski; Matthew P Walker Journal: Nat Rev Neurosci Date: 2017-05-18 Impact factor: 34.870