BACKGROUND: Factor VII activating protease (FSAP) is a circulating serine protease strongly expressed in unstable plaques and may serve as a marker of plaque destabilization. The aim of this study was to examine the relation between plasma concentrations of FSAP and clinical instability and outcome in coronary artery disease (CAD). METHODS AND RESULTS: Circulating FSAP concentration and activity, as well as FSAP mRNA expression in monocytes, were measured in 231 sequential patients who underwent coronary angiography because of stable angina pectoris (n=50), unstable angina pectoris (n=43), or acute myocardial infarction (n=87). FSAP activity, but not FSAP antigen concentration, was elevated in patients with CAD compared with a control group. Elevated FSAP activity (≥1.035 plasma equivalent units [PEU]/ml) indicated a significantly increased risk of death or non-fatal myocardial infarction during 1 year of follow-up as compared with patients with low activity of FSAP (odds ratio 1.895 [95% confidence interval 1.093-3.283]; P=0.023). Furthermore, there were no significant changes in the FSAP expression in monocytes from CAD and control subjects in the basal state but there were differences after stimulation with proinflammatory factors. CONCLUSIONS: Plasma FSAP activity was significantly increased in patients with acute coronary syndrome and may be involved in the pathogenesis of these conditions. High levels of FSAP activity were predictive of adverse events during follow-up, suggesting its potential role in risk stratification and clinical management of CAD patients.
BACKGROUND:Factor VII activating protease (FSAP) is a circulating serine protease strongly expressed in unstable plaques and may serve as a marker of plaque destabilization. The aim of this study was to examine the relation between plasma concentrations of FSAP and clinical instability and outcome in coronary artery disease (CAD). METHODS AND RESULTS: Circulating FSAP concentration and activity, as well as FSAP mRNA expression in monocytes, were measured in 231 sequential patients who underwent coronary angiography because of stable angina pectoris (n=50), unstable angina pectoris (n=43), or acute myocardial infarction (n=87). FSAP activity, but not FSAP antigen concentration, was elevated in patients with CAD compared with a control group. Elevated FSAP activity (≥1.035 plasma equivalent units [PEU]/ml) indicated a significantly increased risk of death or non-fatal myocardial infarction during 1 year of follow-up as compared with patients with low activity of FSAP (odds ratio 1.895 [95% confidence interval 1.093-3.283]; P=0.023). Furthermore, there were no significant changes in the FSAP expression in monocytes from CAD and control subjects in the basal state but there were differences after stimulation with proinflammatory factors. CONCLUSIONS: Plasma FSAP activity was significantly increased in patients with acute coronary syndrome and may be involved in the pathogenesis of these conditions. High levels of FSAP activity were predictive of adverse events during follow-up, suggesting its potential role in risk stratification and clinical management of CAD patients.
Authors: Mariana S Parahuleva; Sandip Kanse; Hans Hölschermann; Kirila Zheleva; Daniel Zandt; Michael Worsch; Behnoush Parviz; Norbert Güttler; Harald Tillmanns; Andreas Böning; Ali Erdogan Journal: J Thromb Thrombolysis Date: 2014-04 Impact factor: 2.300
Authors: Charlotte E Daly; Leong L Ng; Amirmansoor Hakimi; Richard Willingale; Donald J L Jones Journal: Anal Chem Date: 2014-01-27 Impact factor: 6.986
Authors: Birgit Markus; Karsten Grote; Michael Worsch; Behnoush Parviz; Andreas Boening; Bernhard Schieffer; Mariana S Parahuleva Journal: PLoS One Date: 2016-09-15 Impact factor: 3.240
Authors: Mariana S Parahuleva; Bernhard Schieffer; Michael Klassen; Michael Worsch; Behnoush Parviz; Hans Hölschermann Journal: Med Sci Monit Date: 2018-06-21
Authors: Yu-Ching Cheng; Tara M Stanne; Anne-Katrin Giese; Weang Kee Ho; Matthew Traylor; Philippe Amouyel; Elizabeth G Holliday; Rainer Malik; Huichun Xu; Steven J Kittner; John W Cole; Jeffrey R O'Connell; John Danesh; Asif Rasheed; Wei Zhao; Stefan Engelter; Caspar Grond-Ginsbach; Yoichiro Kamatani; Mark Lathrop; Didier Leys; Vincent Thijs; Tiina M Metso; Turgut Tatlisumak; Alessandro Pezzini; Eugenio A Parati; Bo Norrving; Steve Bevan; Peter M Rothwell; Cathie Sudlow; Agnieszka Slowik; Arne Lindgren; Matthew R Walters; Jim Jannes; Jess Shen; David Crosslin; Kimberly Doheny; Cathy C Laurie; Sandip M Kanse; Joshua C Bis; Myriam Fornage; Thomas H Mosley; Jemma C Hopewell; Konstantin Strauch; Martina Müller-Nurasyid; Christian Gieger; Melanie Waldenberger; Annette Peters; Christine Meisinger; M Arfan Ikram; W T Longstreth; James F Meschia; Sudha Seshadri; Pankaj Sharma; Bradford Worrall; Christina Jern; Christopher Levi; Martin Dichgans; Giorgio B Boncoraglio; Hugh S Markus; Stephanie Debette; Arndt Rolfs; Danish Saleheen; Braxton D Mitchell Journal: Stroke Date: 2016-01-05 Impact factor: 7.914
Authors: M Olsson; T M Stanne; A Pedersen; E Lorentzen; E Kara; A Martinez-Palacian; N P Rønnow Sand; A F Jacobsen; P M Sandset; J J Sidelmann; G Engström; O Melander; S M Kanse; C Jern Journal: J Thromb Haemost Date: 2018-08-24 Impact factor: 5.824