Literature DB >> 22846151

High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene.

G Maroteaux1, M Loos, S van der Sluis, B Koopmans, E Aarts, K van Gassen, A Geurts, D A Largaespada, B M Spruijt, O Stiedl, A B Smit, M Verhage.   

Abstract

Recognizing and avoiding aversive situations are central aspects of mammalian cognition. These abilities are essential for health and survival and are expected to have a prominent genetic basis. We modeled these abilities in eight common mouse inbred strains covering ∼75% of the species' natural variation and in gene-trap mice (>2000 mice), using an unsupervised, automated assay with an instrumented home cage (PhenoTyper) containing a shelter with two entrances. Mice visited this shelter for 20-1200 times/24 h and 71% of all mice developed a significant and often strong preference for one entrance. Subsequently, a mild aversive stimulus (shelter illumination) was automatically delivered when mice used their preferred entrance. Different genotypes developed different coping strategies. Firstly, the number of entries via the preferred entrance decreased in DBA/2J, C57BL/6J and 129S1/SvImJ, indicating that these genotypes associated one specific entrance with the aversive stimulus. Secondly, mice started sleeping outside (C57BL/6J, DBA/2J), indicating they associated the shelter, in general, with the aversive stimulus. Some mice showed no evidence for an association between the entrance and the aversive light, but did show markedly shorter shelter residence times in response to illumination, indicating they did perceive illumination as aversive. Finally, using this assay, we screened 43 different mutants, which yielded a novel gene, specc1/cytospinB. This mutant showed profound and specific delay in avoidance learning. Together, these data suggest that different genotypes express distinct learning and/or memory of associations between shelter entrance and aversive stimuli, and that specc1/cytospinB is involved in this aspect of cognition.
© 2012 Vrije Universiteit Amsterdam. Genes, Brain and Behavior © 2012 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

Entities:  

Mesh:

Substances:

Year:  2012        PMID: 22846151      PMCID: PMC3508728          DOI: 10.1111/j.1601-183X.2012.00820.x

Source DB:  PubMed          Journal:  Genes Brain Behav        ISSN: 1601-183X            Impact factor:   3.449


  43 in total

1.  Influence of circadian phase and test illumination on pre-clinical models of anxiety.

Authors:  N Jones; S M King
Journal:  Physiol Behav       Date:  2001-01

2.  Inbred strain variation in contextual and cued fear conditioning behavior.

Authors:  V J Bolivar; O Pooler; L Flaherty
Journal:  Mamm Genome       Date:  2001-08       Impact factor: 2.957

Review 3.  EthoVision: a versatile video tracking system for automation of behavioral experiments.

Authors:  L P Noldus; A J Spink; R A Tegelenbosch
Journal:  Behav Res Methods Instrum Comput       Date:  2001-08

Review 4.  In need of high-throughput behavioral systems.

Authors:  Dani Brunner; Eric Nestler; Emer Leahy
Journal:  Drug Discov Today       Date:  2002-09-15       Impact factor: 7.851

5.  Familial influences on sustained attention and inhibition in preschoolers.

Authors:  Alexia S Groot; Leo M J de Sonneville; John F Stins; Dorret I Boomsma
Journal:  J Child Psychol Psychiatry       Date:  2004-02       Impact factor: 8.982

6.  Time-dependent processes in memory storage.

Authors:  J L McGaugh
Journal:  Science       Date:  1966-09-16       Impact factor: 47.728

Review 7.  Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains.

Authors:  Rachel A Millstein; Andrew Holmes
Journal:  Neurosci Biobehav Rev       Date:  2006-09-06       Impact factor: 8.989

8.  Finding the right motivation: genotype-dependent differences in effective reinforcements for spatial learning.

Authors:  Jiun Youn; Bart A Ellenbroek; Inti van Eck; Sandra Roubos; Matthijs Verhage; Oliver Stiedl
Journal:  Behav Brain Res       Date:  2011-09-29       Impact factor: 3.332

9.  Genetic and behavioral differences among five inbred mouse strains commonly used in the production of transgenic and knockout mice.

Authors:  G W M Bothe; V J Bolivar; M J Vedder; J G Geistfeld
Journal:  Genes Brain Behav       Date:  2004-06       Impact factor: 3.449

Review 10.  Knockout mice: simple solutions to the problems of genetic background and flanking genes.

Authors:  David P Wolfer; Wim E Crusio; Hans Peter Lipp
Journal:  Trends Neurosci       Date:  2002-07       Impact factor: 13.837

View more
  22 in total

Review 1.  Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives.

Authors:  Martien J Kas; Jeffrey C Glennon; Jan Buitelaar; Elodie Ey; Barbara Biemans; Jacqueline Crawley; Robert H Ring; Clara Lajonchere; Frederic Esclassan; John Talpos; Lucas P J J Noldus; J Peter H Burbach; Thomas Steckler
Journal:  Psychopharmacology (Berl)       Date:  2013-09-19       Impact factor: 4.530

2.  Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping.

Authors:  G Maroteaux; T M Arefin; L-A Harsan; E Darcq; S Ben Hamida; B L Kieffer
Journal:  Genes Brain Behav       Date:  2018-04-19       Impact factor: 3.449

3.  Accelerated decline in cognition in a mouse model of increased oxidative stress.

Authors:  Sreemathi Logan; Gordon H Royce; Daniel Owen; Julie Farley; Michelle Ranjo-Bishop; William E Sonntag; Sathyaseelan S Deepa
Journal:  Geroscience       Date:  2019-10-22       Impact factor: 7.713

4.  Within-strain variation in behavior differs consistently between common inbred strains of mice.

Authors:  Maarten Loos; Bastijn Koopmans; Emmeke Aarts; Gregoire Maroteaux; Sophie van der Sluis; Matthijs Verhage; August B Smit
Journal:  Mamm Genome       Date:  2015-06-28       Impact factor: 2.957

5.  Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis.

Authors:  Matthew P Baier; Raghavendra Y Nagaraja; Hannah P Yarbrough; Daniel B Owen; Anthony M Masingale; Rojina Ranjit; Megan A Stiles; Ashley Murphy; Martin-Paul Agbaga; Mohiuddin Ahmad; David M Sherry; Michael T Kinter; Holly Van Remmen; Sreemathi Logan
Journal:  J Neurosci       Date:  2022-06-27       Impact factor: 6.709

6.  Cognitive impact of cytotoxic agents in mice.

Authors:  R Seigers; M Loos; O Van Tellingen; W Boogerd; A B Smit; S B Schagen
Journal:  Psychopharmacology (Berl)       Date:  2014-06-04       Impact factor: 4.530

7.  Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.

Authors:  Sreemathi Logan; Daniel Owen; Sixia Chen; Wei-Jen Chen; Zoltan Ungvari; Julie Farley; Anna Csiszar; Amanda Sharpe; Maarten Loos; Bastijn Koopmans; Arlan Richardson; William E Sonntag
Journal:  Geroscience       Date:  2018-04-24       Impact factor: 7.713

8.  Behavioral response of Caenorhabditis elegans to localized thermal stimuli.

Authors:  Aylia Mohammadi; Jarlath Byrne Rodgers; Ippei Kotera; William S Ryu
Journal:  BMC Neurosci       Date:  2013-07-03       Impact factor: 3.288

9.  Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model.

Authors:  Ioannis Kramvis; Huibert D Mansvelder; Maarten Loos; Rhiannon Meredith
Journal:  Front Behav Neurosci       Date:  2013-11-21       Impact factor: 3.558

10.  Short and long term measures of anxiety exhibit opposite results.

Authors:  Ehud Fonio; Yoav Benjamini; Ilan Golani
Journal:  PLoS One       Date:  2012-10-31       Impact factor: 3.240

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.