Literature DB >> 22842475

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.

Bérengère Fromy1, Eric Lingueglia, Dominique Sigaudo-Roussel, Jean Louis Saumet, Michel Lazdunski.   

Abstract

Pressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.

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Year:  2012        PMID： 22842475     DOI： 10.1038/nm.2844

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  31 in total

1.  A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.

Authors:  Sylvie Diochot; Anne Baron; Lachlan D Rash; Emmanuel Deval; Pierre Escoubas; Sabine Scarzello; Miguel Salinas; Michel Lazdunski
Journal:  EMBO J       Date:  2004-03-25       Impact factor: 11.598

Review 2.  Peptides inhibitors of acid-sensing ion channels.

Authors:  S Diochot; M Salinas; A Baron; P Escoubas; M Lazdunski
Journal:  Toxicon       Date:  2006-10-04       Impact factor: 3.033

3.  Non-nociceptive capsaicin-sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin.

Authors:  B Fromy; P Abraham; J L Saumet
Journal:  Brain Res       Date:  1998-11-16       Impact factor: 3.252

4.  Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.

Authors:  R Waldmann; F Bassilana; J de Weille; G Champigny; C Heurteaux; M Lazdunski
Journal:  J Biol Chem       Date:  1997-08-22       Impact factor: 5.157

5.  Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Authors:  C C Wykoff; N J Beasley; P H Watson; K J Turner; J Pastorek; A Sibtain; G D Wilson; H Turley; K L Talks; P H Maxwell; C W Pugh; P J Ratcliffe; A L Harris
Journal:  Cancer Res       Date:  2000-12-15       Impact factor: 12.701

6.  Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy.

Authors:  Claire Demiot; Maylis Tartas; Bérengère Fromy; Pierre Abraham; Jean Louis Saumet; Dominique Sigaudo-Roussel
Journal:  Diabetes       Date:  2006-05       Impact factor: 9.461

7.  Pressure ulcers, hospital complications, and disease severity: impact on hospital costs and length of stay.

Authors:  R M Allman; P S Goode; N Burst; A A Bartolucci; D R Thomas
Journal:  Adv Wound Care       Date:  1999 Jan-Feb       Impact factor: 4.730

8.  Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function.

Authors:  A J Page; S M Brierley; C M Martin; M P Price; E Symonds; R Butler; J A Wemmie; L A Blackshaw
Journal:  Gut       Date:  2005-06-29       Impact factor: 23.059

9.  ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons.

Authors:  Derek C Molliver; David C Immke; Leonardo Fierro; Michel Paré; Frank L Rice; Edwin W McCleskey
Journal:  Mol Pain       Date:  2005-11-23       Impact factor: 3.395

10.  Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis.

Authors:  Thomas Wultsch; Evelin Painsipp; Anaid Shahbazian; Martina Mitrovic; Martin Edelsbrunner; Michel Lazdunski; Rainer Waldmann; Peter Holzer
Journal:  Pain       Date:  2007-05-24       Impact factor: 7.926
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  30 in total

1.  Amiloride treatment and increased risk of pressure ulcers in hospitalized patients.

Authors:  Matthieu Roustit; Céline Genty; Marion Lepelley; Sophie Blaise; Bérengère Fromy; Jean-Luc Cracowski; Jean-Luc Bosson
Journal:  Br J Clin Pharmacol       Date:  2016-09-18       Impact factor: 4.335

2.  ASIC3 fine-tunes bladder sensory signaling.

Authors:  Nicolas Montalbetti; James G Rooney; Allison L Marciszyn; Marcelo D Carattino
Journal:  Am J Physiol Renal Physiol       Date:  2018-03-21

Review 3.  Acid-sensing ion channels in sensory signaling.

Authors:  Marcelo D Carattino; Nicolas Montalbetti
Journal:  Am J Physiol Renal Physiol       Date:  2020-01-27

4.  Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions.

Authors:  Anne Delaunay; Xavier Gasull; Miguel Salinas; Jacques Noël; Valérie Friend; Eric Lingueglia; Emmanuel Deval
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-24       Impact factor: 11.205

5.  Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid.

Authors:  Xiao-Gang Yan; Wei-Guang Li; Xin Qi; Jia-Jie Zhu; Chen Huang; Shao-Ling Han; Qin Jiang; Tian-Le Xu; Jian-Hua Liu
Journal:  CNS Neurosci Ther       Date:  2018-05-20       Impact factor: 5.243

6.  Acid-sensing ion channels modulate bladder nociception.

Authors:  Nicolas Montalbetti; Marcelo D Carattino
Journal:  Am J Physiol Renal Physiol       Date:  2021-09-13

7.  Black mamba venom peptides target acid-sensing ion channels to abolish pain.

Authors:  Sylvie Diochot; Anne Baron; Miguel Salinas; Dominique Douguet; Sabine Scarzello; Anne-Sophie Dabert-Gay; Delphine Debayle; Valérie Friend; Abdelkrim Alloui; Michel Lazdunski; Eric Lingueglia
Journal:  Nature       Date:  2012-10-03       Impact factor: 49.962

8.  Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids.

Authors:  Sébastien Marra; Romain Ferru-Clément; Véronique Breuil; Anne Delaunay; Marine Christin; Valérie Friend; Stéphane Sebille; Christian Cognard; Thierry Ferreira; Christian Roux; Liana Euller-Ziegler; Jacques Noel; Eric Lingueglia; Emmanuel Deval
Journal:  EMBO J       Date:  2016-01-15       Impact factor: 11.598

Review 9.  Acid-sensing ion channels in pain and disease.

Authors:  John A Wemmie; Rebecca J Taugher; Collin J Kreple
Journal:  Nat Rev Neurosci       Date:  2013-07       Impact factor: 34.870

Review 10.  Acid-sensing ion channels contribute to neurotoxicity.

Authors:  Xiang-Ping Chu; Kenneth A Grasing; John Q Wang
Journal:  Transl Stroke Res       Date:  2013-11-16       Impact factor: 6.829
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