Literature DB >> 22842145

Direct gating and mechanical integrity of Drosophila auditory transducers require TRPN1.

Thomas Effertz1, Björn Nadrowski, David Piepenbrock, Jörg T Albert, Martin C Göpfert.   

Abstract

The elusive transduction channels for hearing are directly gated mechanically by the pull of gating springs. We found that the transient receptor potential (TRP) channel TRPN1 (NOMPC) is essential for this direct gating of Drosophila auditory transduction channels and that the channel-spring complex was disrupted if TRPN1 was lost. Our results identify TRPN1 as a mechanical constituent of the fly's auditory transduction complex that may act as the channel and/or gating spring.

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Year:  2012        PMID： 22842145     DOI： 10.1038/nn.3175

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  17 in total

1.  Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors.

Authors:  Jonathon Howard; Susanne Bechstedt
Journal:  Curr Biol       Date:  2004-03-23       Impact factor: 10.834

2.  Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells.

Authors:  Jung-Bum Shin; Dany Adams; Martin Paukert; Maria Siba; Samuel Sidi; Michael Levin; Peter G Gillespie; Stefan Gründer
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-22       Impact factor: 11.205

3.  Specification of auditory sensitivity by Drosophila TRP channels.

Authors:  Martin C Göpfert; Jörg T Albert; B Nadrowski; A Kamikouchi
Journal:  Nat Neurosci       Date:  2006-07-02       Impact factor: 24.884

4.  NompC TRP channel is essential for Drosophila sound receptor function.

Authors:  Thomas Effertz; Robert Wiek; Martin C Göpfert
Journal:  Curr Biol       Date:  2011-03-31       Impact factor: 10.834

5.  C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel.

Authors:  Lijun Kang; Jingwei Gao; William R Schafer; Zhixiong Xie; X Z Shawn Xu
Journal:  Neuron       Date:  2010-08-12       Impact factor: 17.173

6.  Transducer-based force generation explains active process in Drosophila hearing.

Authors:  Björn Nadrowski; Jörg T Albert; Martin C Göpfert
Journal:  Curr Biol       Date:  2008-09-11       Impact factor: 10.834

7.  Unifying the various incarnations of active hair-bundle motility by the vertebrate hair cell.

Authors:  Jean-Yves Tinevez; Frank Jülicher; Pascal Martin
Journal:  Biophys J       Date:  2007-08-17       Impact factor: 4.033

8.  NompC TRP channel required for vertebrate sensory hair cell mechanotransduction.

Authors:  Samuel Sidi; Rainer W Friedrich; Teresa Nicolson
Journal:  Science       Date:  2003-06-12       Impact factor: 47.728

9.  Power gain exhibited by motile mechanosensory neurons in Drosophila ears.

Authors:  M C Göpfert; A D L Humphris; J T Albert; D Robert; O Hendrich
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-28       Impact factor: 11.205

10.  Distinct sensory representations of wind and near-field sound in the Drosophila brain.

Authors:  Suzuko Yorozu; Allan Wong; Brian J Fischer; Heiko Dankert; Maurice J Kernan; Azusa Kamikouchi; Kei Ito; David J Anderson
Journal:  Nature       Date:  2009-03-12       Impact factor: 49.962
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  31 in total

Review 1.  Active amplification in insect ears: mechanics, models and molecules.

Authors:  Natasha Mhatre
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2014-12-11       Impact factor: 1.836

2.  A Mechanosensory Circuit that Mixes Opponent Channels to Produce Selectivity for Complex Stimulus Features.

Authors:  Allison E B Chang; Alex G Vaughan; Rachel I Wilson
Journal:  Neuron       Date:  2016-10-27       Impact factor: 17.173

3.  The Basis of Food Texture Sensation in Drosophila.

Authors:  Yali V Zhang; Timothy J Aikin; Zhengzheng Li; Craig Montell
Journal:  Neuron       Date:  2016-07-28       Impact factor: 17.173

Review 4.  Genes and circuits of courtship behaviour in Drosophila males.

Authors:  Daisuke Yamamoto; Masayuki Koganezawa
Journal:  Nat Rev Neurosci       Date:  2013-10       Impact factor: 34.870

Review 5.  The Drosophila auditory system.

Authors:  Grace Boekhoff-Falk; Daniel F Eberl
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2013-10-16       Impact factor: 5.814

Review 6.  Neuronal encoding of sound, gravity, and wind in the fruit fly.

Authors:  Eriko Matsuo; Azusa Kamikouchi
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2013-03-13       Impact factor: 1.836

7.  Reception and learning of electric fields in bees.

Authors:  Uwe Greggers; Gesche Koch; Viola Schmidt; Aron Dürr; Amalia Floriou-Servou; David Piepenbrock; Martin C Göpfert; Randolf Menzel
Journal:  Proc Biol Sci       Date:  2013-03-27       Impact factor: 5.349

8.  Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies.

Authors:  Kartik Venkatachalam; Junjie Luo; Craig Montell
Journal:  Handb Exp Pharmacol       Date:  2014

Review 9.  Mechanically Activated Ion Channels.

Authors:  Sanjeev S Ranade; Ruhma Syeda; Ardem Patapoutian
Journal:  Neuron       Date:  2015-09-23       Impact factor: 17.173

10.  RNA interference supports a role for Nanchung-Inactive in mechanotransduction by the cockroach, Periplaneta americana, tactile spine.

Authors:  Anneka Hennenfent; Hongxia Liu; Päivi H Torkkeli; Andrew S French
Journal:  Invert Neurosci       Date:  2020-01-21
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