Mitchell D Eggers1, Charles A Reitman. 1. Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA. mitcheggers@yahoo.com
Abstract
PURPOSE: To test absorbable materials as a prelude to development of an absorbable vena cava filter for the prevention of pulmonary embolism (PE). MATERIALS AND METHODS: Three absorbing polymer candidates, poliglecaprone (Monocryl; sizes 4-0 and 1), polyglactin (Vicryl; sizes 4-0 and 1), and polydioxanone (PDSII; sizes 4-0, 2-0, 0, and 1), were fabricated into vascular filters and evaluated in an engineered closed circulation system that replicated human physiologic characteristics. Material performance was determined over a period of 10 weeks via weekly tensile testing, yielding stress-versus-strain parameters. Control samples of the same absorbable polymers were also tested in a static buffer. RESULTS: PDSII (size 2-0) retained 69% strength in circulation versus 86% in control at 6 weeks (P < .0001) and 11% strength in circulation versus 51% in control at 10 weeks (P < .001). It was fully absorbed in circulation by 22 weeks. In contrast, Monocryl and Vicryl absorbed much faster, with Monocryl possessing 6% strength at 2 weeks in circulation and Vicryl reaching 0% strength at 4 weeks. CONCLUSIONS: Polydioxanone appears to be a strong candidate for novel absorbable vascular filters for PE prevention, with sufficient strength retention to catch emboli for at least 6 weeks and sequentially absorb via hydrolysis into CO(2) and H(2)O within 22 weeks.
PURPOSE: To test absorbable materials as a prelude to development of an absorbable vena cava filter for the prevention of pulmonary embolism (PE). MATERIALS AND METHODS: Three absorbing polymer candidates, poliglecaprone (Monocryl; sizes 4-0 and 1), polyglactin (Vicryl; sizes 4-0 and 1), and polydioxanone (PDSII; sizes 4-0, 2-0, 0, and 1), were fabricated into vascular filters and evaluated in an engineered closed circulation system that replicated human physiologic characteristics. Material performance was determined over a period of 10 weeks via weekly tensile testing, yielding stress-versus-strain parameters. Control samples of the same absorbable polymers were also tested in a static buffer. RESULTS:PDSII (size 2-0) retained 69% strength in circulation versus 86% in control at 6 weeks (P < .0001) and 11% strength in circulation versus 51% in control at 10 weeks (P < .001). It was fully absorbed in circulation by 22 weeks. In contrast, Monocryl and Vicryl absorbed much faster, with Monocryl possessing 6% strength at 2 weeks in circulation and Vicryl reaching 0% strength at 4 weeks. CONCLUSIONS:Polydioxanone appears to be a strong candidate for novel absorbable vascular filters for PE prevention, with sufficient strength retention to catch emboli for at least 6 weeks and sequentially absorb via hydrolysis into CO(2) and H(2)O within 22 weeks.
Authors: Steven Y Huang; Jossana A Damasco; Li Tian; Linfeng Lu; Joy Vanessa D Perez; Katherine A Dixon; Malea L Williams; Megan C Jacobsen; Stephen J Dria; Mitchell D Eggers; Adam D Melancon; Rick R Layman; Elizabeth M Whitley; Marites P Melancon Journal: Biomater Sci Date: 2020-06-19 Impact factor: 6.843
Authors: Burapol Singhana; Aaron Chen; Patrick Slattery; Iman K Yazdi; Yang Qiao; Ennio Tasciotti; Michael Wallace; Steven Huang; Mitch Eggers; Marites P Melancon Journal: J Mater Sci Mater Med Date: 2015-02-18 Impact factor: 3.896
Authors: Li Tian; Patrick Lee; Burapol Singhana; Aaron Chen; Yang Qiao; Linfeng Lu; Jonathan O Martinez; Ennio Tasciotti; Adam Melancon; Steven Huang; Mitch Eggers; Marites P Melancon Journal: Sci Rep Date: 2017-05-19 Impact factor: 4.379