Literature DB >> 22836518

Hydroxamate represents a versatile zinc binding group for the development of new carbonic anhydrase inhibitors.

Anna Di Fiore1, Alfonso Maresca, Claudiu T Supuran, Giuseppina De Simone.   

Abstract

Hydroxamates (R-CONHOH) have been scarcely investigated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs). An inhibition/structural study of PhCONHOH is reported against all human isoforms. Comparing aliphatic (R = Me and CF(3)) and aromatic (R = Ph) hydroxamates as CAIs, we prove that CONHOH is a versatile zinc binding group. Depending on the nature of the R moiety, it can adopt different coordination modes to the catalytic ion within the CA active site.

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Year:  2012        PMID： 22836518     DOI： 10.1039/c2cc34275h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

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2.  Pull-Down of Metalloproteins in Their Native States by Using Desthiobiotin-Based Probes.

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4.  Metal-Binding Isosteres as New Scaffolds for Metalloenzyme Inhibitors.

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5.  Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?

Authors:  Claudiu T Supuran
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6.  Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors.

Authors:  Morteza Abdoli; Murat Bozdag; Andrea Angeli; Claudiu T Supuran
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7.  New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases.

Authors:  Yosselin Huentupil; Luis Peña; Néstor Novoa; Emanuela Berrino; Rodrigo Arancibia; Claudiu T Supuran
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Review 8.  Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase.

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Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

9.  A Proof-of-Concept Fragment Screening of a Hit-Validated 96-Compounds Library against Human Carbonic Anhydrase II.

Authors:  Steffen Glöckner; Andreas Heine; Gerhard Klebe
Journal:  Biomolecules       Date:  2020-03-29

10.  A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer.

Authors:  Jessica Ruzzolini; Anna Laurenzana; Elena Andreucci; Silvia Peppicelli; Francesca Bianchini; Fabrizio Carta; Claudiu T Supuran; Maria Novella Romanelli; Chiara Nediani; Lido Calorini
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  10 in total

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