PURPOSE: Hypolipidemic and/or hypocholesterolemic effects are presumed for dietary milk phospholipid (PL) as well as plant sterol (PSt) supplementation. The aim was to induce changes in plasma lipid profile by giving different doses of milk PL and a combination of milk PL with PSt to healthy volunteers. METHODS: In an open-label intervention study, 14 women received dairy products enriched with moderate (3 g PL/day) or high (6 g PL/day) dose of milk PL or a high dose of milk PL combined with PSt (6 g PL/day + 2 g PSt/day) during 3 periods each lasting 10 days. RESULTS: Total cholesterol concentration and HDL cholesterol concentration were reduced following supplementation with 3 g PL/day. No significant change in LDL cholesterol concentration was found compared with baseline. High PL dose resulted in an increase of LDL cholesterol and unchanged HDL cholesterol compared with moderate PL dose. The LDL/HDL ratio and triglyceride concentration remained constant within the study. Except for increased phosphatidyl ethanolamine concentrations, plasma PL concentrations were not altered during exclusive PL supplementations. A combined high-dose PL and PSt supplementation led to decreased plasma LDL cholesterol concentration, decreased PL excretion, increased plasma sphingomyelin/phosphatidyl choline ratio, and significant changes in plasma fatty acid distribution compared with exclusive high-dose PL supplementation. CONCLUSION: Milk PL supplementations influence plasma cholesterol concentrations, but without changes of LDL/HDL ratio. A combined high-dose milk PL and PSt supplementation decreases plasma LDL cholesterol concentration, but it probably enforces absorption of fatty acids or fatty acid-containing hydrolysis products that originated during lipid digestion.
PURPOSE: Hypolipidemic and/or hypocholesterolemic effects are presumed for dietary milk phospholipid (PL) as well as plant sterol (PSt) supplementation. The aim was to induce changes in plasma lipid profile by giving different doses of milk PL and a combination of milk PL with PSt to healthy volunteers. METHODS: In an open-label intervention study, 14 women received dairy products enriched with moderate (3 g PL/day) or high (6 g PL/day) dose of milk PL or a high dose of milk PL combined with PSt (6 g PL/day + 2 g PSt/day) during 3 periods each lasting 10 days. RESULTS: Total cholesterol concentration and HDL cholesterol concentration were reduced following supplementation with 3 g PL/day. No significant change in LDL cholesterol concentration was found compared with baseline. High PL dose resulted in an increase of LDL cholesterol and unchanged HDL cholesterol compared with moderate PL dose. The LDL/HDL ratio and triglyceride concentration remained constant within the study. Except for increased phosphatidyl ethanolamine concentrations, plasma PL concentrations were not altered during exclusive PL supplementations. A combined high-dose PL and PSt supplementation led to decreased plasma LDL cholesterol concentration, decreased PL excretion, increased plasma sphingomyelin/phosphatidyl choline ratio, and significant changes in plasma fatty acid distribution compared with exclusive high-dose PL supplementation. CONCLUSION: Milk PL supplementations influence plasma cholesterol concentrations, but without changes of LDL/HDL ratio. A combined high-dose milk PL and PSt supplementation decreases plasma LDL cholesterol concentration, but it probably enforces absorption of fatty acids or fatty acid-containing hydrolysis products that originated during lipid digestion.
Authors: Tim Vanmierlo; Oliver Weingärtner; Susanne van der Pol; Constanze Husche; Anja Kerksiek; Silvia Friedrichs; Eric Sijbrands; Harry Steinbusch; Marcus Grimm; Tobias Hartmann; Ulrich Laufs; Michael Böhm; Helga E de Vries; Monique Mulder; Dieter Lütjohann Journal: J Lipid Res Date: 2012-01-25 Impact factor: 5.922
Authors: Daniel Teupser; Ronny Baber; Uta Ceglarek; Markus Scholz; Thomas Illig; Christian Gieger; Lesca M Holdt; Alexander Leichtle; Karin H Greiser; Dominik Huster; Patrick Linsel-Nitschke; Arne Schäfer; Peter S Braund; Laurence Tiret; Klaus Stark; Dorette Raaz-Schrauder; Georg M Fiedler; Wolfgang Wilfert; Frank Beutner; Stephan Gielen; Anika Grosshennig; Inke R König; Peter Lichtner; Iris M Heid; Alexander Kluttig; Nour E El Mokhtari; Diana Rubin; Arif B Ekici; André Reis; Christoph D Garlichs; Alistair S Hall; Gert Matthes; Christian Wittekind; Christian Hengstenberg; Francois Cambien; Stefan Schreiber; Karl Werdan; Thomas Meitinger; Markus Loeffler; Nilesh J Samani; Jeanette Erdmann; H-Erich Wichmann; Heribert Schunkert; Joachim Thiery Journal: Circ Cardiovasc Genet Date: 2010-06-07