Literature DB >> 22834877

Current landscape of phosphodiesterase 10A (PDE10A) inhibition.

Thomas A Chappie1, Christopher J Helal, Xinjun Hou.   

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Year:  2012        PMID： 22834877     DOI： 10.1021/jm3004976

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  17 in total

1.  PDE10 Inhibitors as Potential Treatment for Schizophrenia.

Authors:  Ahmed F Abdel-Magid
Journal:  ACS Med Chem Lett       Date:  2013-01-25       Impact factor: 4.345

2.  Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.

Authors:  Junfeng Li; Xiang Zhang; Hongjun Jin; Jinda Fan; Hubert Flores; Joel S Perlmutter; Zhude Tu
Journal:  J Med Chem       Date:  2015-10-15       Impact factor: 7.446

3.  Structural findings of cinnolines as anti-schizophrenic PDE10A inhibitors through comparative chemometric modeling.

Authors:  Chanchal Mondal; Amit Kumar Halder; Nilanjan Adhikari; Tarun Jha
Journal:  Mol Divers       Date:  2014-05-01       Impact factor: 2.943

4.  A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios.

Authors:  Andreas Tosstorff; Markus G Rudolph; Jason C Cole; Michael Reutlinger; Christian Kramer; Hervé Schaffhauser; Agnès Nilly; Alexander Flohr; Bernd Kuhn
Journal:  J Comput Aided Mol Des       Date:  2022-09-25       Impact factor: 4.179

5.  Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject.

Authors:  Hui Liu; Hongjun Jin; Xuyi Yue; Xiang Zhang; Hao Yang; Junfeng Li; Hubert Flores; Yi Su; Joel S Perlmutter; Zhude Tu
Journal:  Neuroimage       Date:  2015-07-26       Impact factor: 6.556

6.  Phosphodiesterase 10A inhibitor MP-10 effects in primates: comparison with risperidone and mechanistic implications.

Authors:  Subramaniam Uthayathas; Gunasingh J Masilamoni; Christopher L Shaffer; Christopher J Schmidt; Frank S Menniti; Stella M Papa
Journal:  Neuropharmacology       Date:  2014-02       Impact factor: 5.250

Review 7.  Recent advances in genetics of chorea.

Authors:  Niccolò E Mencacci; Miryam Carecchio
Journal:  Curr Opin Neurol       Date:  2016-08       Impact factor: 5.710

8.  Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.

Authors:  Michael I Recht; Vandana Sridhar; John Badger; Pierre-Yves Bounaud; Cheyenne Logan; Barbara Chie-Leon; Vicki Nienaber; Francisco E Torres
Journal:  J Biomol Screen       Date:  2013-12-27

9.  Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32

Authors:  Marina Polito; Elvire Guiot; Giuseppe Gangarossa; Sophie Longueville; Mohamed Doulazmi; Emmanuel Valjent; Denis Hervé; Jean-Antoine Girault; Danièle Paupardin-Tritsch; Liliana R V Castro; Pierre Vincent
Journal:  eNeuro       Date:  2015-08-31

10.  De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions.

Authors:  Niccolò E Mencacci; Erik-Jan Kamsteeg; Kosuke Nakashima; Lea R'Bibo; David S Lynch; Bettina Balint; Michèl A A P Willemsen; Matthew E Adams; Sarah Wiethoff; Kazunori Suzuki; Ceri H Davies; Joanne Ng; Esther Meyer; Liana Veneziano; Paola Giunti; Deborah Hughes; F Lucy Raymond; Miryam Carecchio; Giovanna Zorzi; Nardo Nardocci; Chiara Barzaghi; Barbara Garavaglia; Vincenzo Salpietro; John Hardy; Alan M Pittman; Henry Houlden; Manju A Kurian; Haruhide Kimura; Lisenka E L M Vissers; Nicholas W Wood; Kailash P Bhatia
Journal:  Am J Hum Genet       Date:  2016-04-07       Impact factor: 11.025
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